target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id MMP12,1636,P39900,Human,compound 20 [PMID: 22153340],6568,,25122902,CC([C@@H](C(=O)O)NS(=O)(=O)c1ccc2c(c1)oc1c2cc(cc1)c1ccc(o1)C)C,"InChI=1S/C22H21NO6S/c1-12(2)21(22(24)25)23-30(26,27)15-6-7-16-17-10-14(18-8-4-13(3)28-18)5-9-19(17)29-20(16)11-15/h4-12,21,23H,1-3H3,(H,24,25)/t21-/m0/s1",LLJREHOWNIBILL-NRFANRHFSA-N,Inhibitor,Inhibition,,,,,pIC50,,10.0,,IC50,,0.1,,=,,,,22153340, MMP12,1636,P39900,Human,ilomastat,7409,,132519,ONC(=O)C[C@H](C(=O)N[C@H](C(=O)NC)Cc1c[nH]c2c1cccc2)CC(C)C,"InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1",NITYDPDXAAFEIT-DYVFJYSZSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.34,,IC50,,0.46,,=,,,,35687819, MMP12,1636,P39900,Human,ilomastat,7409,,132519,ONC(=O)C[C@H](C(=O)N[C@H](C(=O)NC)Cc1c[nH]c2c1cccc2)CC(C)C,"InChI=1S/C20H28N4O4/c1-12(2)8-13(10-18(25)24-28)19(26)23-17(20(27)21-3)9-14-11-22-16-7-5-4-6-15(14)16/h4-7,11-13,17,22,28H,8-10H2,1-3H3,(H,21,27)(H,23,26)(H,24,25)/t13-,17+/m1/s1",NITYDPDXAAFEIT-DYVFJYSZSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.89,,IC50,,13.0,,=,,,,14684295, MMP12,1636,P39900,Human,RXP470.1,7812,,44580458,OC(=O)CC[C@@H](C(=O)N[C@H](C(=O)N)CCC(=O)O)NC(=O)[C@@H](CP(=O)(c1ccc(cc1)Br)O)Cc1onc(c1)c1ccc(cc1)c1cccc(c1)Cl,"InChI=1S/C35H35BrClN4O10P/c36-24-8-10-27(11-9-24)52(49,50)19-23(34(47)40-29(13-15-32(44)45)35(48)39-28(33(38)46)12-14-31(42)43)17-26-18-30(41-51-26)21-6-4-20(5-7-21)22-2-1-3-25(37)16-22/h1-11,16,18,23,28-29H,12-15,17,19H2,(H2,38,46)(H,39,48)(H,40,47)(H,42,43)(H,44,45)(H,49,50)/t23-,28+,29+/m1/s1",PTUCPHGSAFOJAU-MGONOCMRSA-N,Inhibitor,Inhibition,,,yes,,pKi,,8.62,,Ki,,2.4,,=,,,,23343195, MMP12,1636,P39900,Human,AZD6605,7823,,11641563,FC(C(Oc1ccc(cc1)OC1CCN(CC1)S(=O)(=O)C[C@@]1(C)NC(=O)NC1=O)(F)F)F,"InChI=1S/C18H21F4N3O6S/c1-17(15(26)23-16(27)24-17)10-32(28,29)25-8-6-12(7-9-25)30-11-2-4-13(5-3-11)31-18(21,22)14(19)20/h2-5,12,14H,6-10H2,1H3,(H2,23,24,26,27)/t17-/m1/s1",SBVAXUGOISPYPX-QGZVFWFLSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.22,,IC50,,0.6,,=,,,,, MMP12,1636,P39900,Human,AZD1236,7844,,24751752,O=C1NC(=O)[C@@](N1)(C)CS(=O)(=O)N1CCC(CC1)Oc1ccc(cn1)Cl,"InChI=1S/C15H19ClN4O5S/c1-15(13(21)18-14(22)19-15)9-26(23,24)20-6-4-11(5-7-20)25-12-3-2-10(16)8-17-12/h2-3,8,11H,4-7,9H2,1H3,(H2,18,19,21,22)/t15-/m1/s1",SFJFBTPHDHUUPU-OAHLLOKOSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.21,,IC50,,6.1,,=,,,,, MMP12,1636,P39900,Human,compound 5 [PMID: 24900526],7869,,66560622,COc1ccc(cc1)S(=O)(=O)N(C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1)CC(C)C)CC(=O)O,"InChI=1S/C28H35N3O9S/c1-19(2)16-23(27(35)31(17-25(32)33)41(37,38)22-13-11-21(39-3)12-14-22)29-26(34)24-10-7-15-30(24)28(36)40-18-20-8-5-4-6-9-20/h4-6,8-9,11-14,19,23-24H,7,10,15-18H2,1-3H3,(H,29,34)(H,32,33)/t23-,24-/m0/s1",QXROXWFFCFLRBZ-ZEQRLZLVSA-N,Inhibitor,Inhibition,This is the prodrug,,,,pIC50,,4.89,,IC50,,13000.0,,=,,,,24900526, MMP12,1636,P39900,Human,compound 1 [PMID: 24900526],7870,,893637,OC(=O)CNS(=O)(=O)c1ccc(cc1)c1ccccc1,"InChI=1S/C14H13NO4S/c16-14(17)10-15-20(18,19)13-8-6-12(7-9-13)11-4-2-1-3-5-11/h1-9,15H,10H2,(H,16,17)",ZIAFXLGSGMQYPL-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.54,,IC50,,290.0,,=,,,,24900526, MMP12,1636,P39900,Human,TP0556351,12057,,163410393,CC(C)C[C@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CCCCNC(=O)c1ccc(Oc2ccc(cc2)C(=O)N)cc1)C(=O)N(C)[C@@H](CCC(=O)O)C(=O)N1CCC[C@H]1CC(=O)N,"InChI=1S/C50H70N10O16/c1-28(2)25-37(49(74)59(3)38(18-20-42(65)66)50(75)60-24-6-7-31(60)26-39(52)61)58-47(72)35(21-22-51)56-48(73)36(27-43(67)68)57-46(71)34(17-19-41(63)64)55-40(62)8-4-5-23-54-45(70)30-11-15-33(16-12-30)76-32-13-9-29(10-14-32)44(53)69/h9-16,28,31,34-38H,4-8,17-27,51H2,1-3H3,(H2,52,61)(H2,53,69)(H,54,70)(H,55,62)(H,56,73)(H,57,71)(H,58,72)(H,63,64)(H,65,66)(H,67,68)/t31-,34-,35-,36-,37-,38-/m0/s1",FVDPKGPPYGTKTO-DLXWRWKMSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.86,,IC50,,1367.0,,=,,,,35687819,