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Targets Associated to Immuno Processes - Tissue repair

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Tissue repair
Enzymes
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
enhancer of zeste 2 polycomb repressive complex 2 subunit
(2.1.1.43 Histone methyltransferases (HMTs))
  • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration (GO:0014834) IEA
EZH2 is involved in hematopoietic stem cell proliferation and differentiation, thymopoiesis and lymphopoiesis, with notable participation in regulating the differentiation and function of T cells. This role suggests potential applications in immune-mediated conditions, including autoimmune disorders [17] ...
Haem oxygenase 1
(Haem oxygenase)
  • wound healing involved in inflammatory response (GO:0002246) IMP
Heme oxygenase (HO) is a rate-limiting enzyme in the catabolism of heme, catalyzing the oxidative cleavage of heme (Fe-protoporphyrin-IX) to render equimolar amounts of biliverdin, ferrous iron (Fe2+), and carbon monoxide (CO).

Heme oxygenase 1 (HO1) is a Nrf2-regulated gene, whose expression is upregulated as a cytoprotective mechanism in response to cellular stresses including inflammation, ischemia, hypoxia, hyperoxia, hyperthermia, or radiation.

HO1 has antioxidant, antiinflammatory, antiapoptotic, antiproliferative, and immunomodulatory effects in vascular cells, playing an important role in the prevention of vascular inflammation and atherogenesis (reviewed in [2] ...
tec protein tyrosine kinase
(Tec family)
  • tissue regeneration (GO:0042246) IBA
The TEC family protein tyrosine kinases have been identified as key components of T-cell-receptor activation and signalling. TEC family kinases are expressed predominantly by haematopoietic cells. T cells express ITK, TXK and TEC [3] ...
TXK tyrosine kinase
(Tec family)
  • tissue regeneration (GO:0042246) IBA
The TEC family protein tyrosine kinases have been identified as key components of T-cell-receptor activation and signalling. TEC family kinases are expressed predominantly by haematopoietic cells. T cells express ITK, TXK and TEC [3] ...
Other Protein Targets
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
advanced glycosylation end-product specific receptor
(Immunoglobulins)
  • negative regulation of connective tissue replacement involved in inflammatory response wound healing (GO:1904597) IEA
RAGE is a single chain, membrane bound immunoglobulin type protein [12,14,23] ...