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GABAA receptor π subunit

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Target not currently curated in GtoImmuPdb

Target id: 419

Nomenclature: GABAA receptor π subunit

Family: GABAA receptors

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 4 440 5q35.1 GABRP gamma-aminobutyric acid type A receptor subunit pi 3
Mouse 4 440 11 A4 Gabrp gamma-aminobutyric acid type A receptor subunit pi 4
Rat 4 440 10q12 Gabrp gamma-aminobutyric acid type A receptor subunit pi 3
Previous and Unofficial Names Click here for help
GABA(A) receptor subunit pi | gamma-aminobutyric acid (GABA-A) receptor, pi | gamma-aminobutyric acid (GABA) A receptor | gamma-aminobutyric acid type A receptor pi subunit
Database Links Click here for help
Alphafold O00591 (Hs), Q8QZW7 (Mm), O09028 (Rn)
CATH/Gene3D 2.70.170.10
ChEMBL Target CHEMBL2093872 (Hs), CHEMBL2094133 (Mm), CHEMBL1907607 (Rn)
DrugBank Target O00591 (Hs), O00591 (Hs)
Ensembl Gene ENSG00000094755 (Hs), ENSMUSG00000020159 (Mm), ENSRNOG00000032417 (Rn)
Entrez Gene 2568 (Hs), 216643 (Mm), 81658 (Rn)
Human Protein Atlas ENSG00000094755 (Hs)
KEGG Gene hsa:2568 (Hs), mmu:216643 (Mm), rno:81658 (Rn)
OMIM 602729 (Hs)
Pharos O00591 (Hs)
RefSeq Nucleotide NM_014211 (Hs), NM_146017 (Mm), NM_031029 (Rn)
RefSeq Protein NP_055026 (Hs), NP_666129 (Mm), NP_112291 (Rn)
UniProtKB O00591 (Hs), Q8QZW7 (Mm), O09028 (Rn)
Wikipedia GABRP (Hs)
Natural/Endogenous Ligands Click here for help
GABA

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Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Use-dependent Value Parameter Concentration range (M) Voltage-dependent (mV) Reference
picrotoxin Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent
TBPS Small molecule or natural product Click here for species-specific activity table Hs - no - - - no
⤷
Not voltage dependent
Tissue Distribution Click here for help
Human tetracarcinoma NT-2 cells and differentiated NT-2N cells
Species:  Human
Technique:  RT-PCR
References:  6
Uterus, lung, thymus, prostate, small intestine, ovaries, placenta
Species:  Human
Technique:  Northern Blot
References:  3
Alevolar epithelial type II cells
Species:  Human
Technique:  RT-PCR and in situ hybridisation.
References:  1
Uterus.
Species:  Rat
Technique:  RNase protection assay, RT-PCR.
References:  2
Gene Expression and Pathophysiology Click here for help
The π subunit is overexpressed in pancreatic adenocarcinomas
Tissue or cell type:  pancreas
Pathophysiology:  adenocarcinoma
Species:  Human
Technique: 
References:  5

References

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1. Chen Z, Jin N, Narasaraju T, Chen J, McFarland LR, Scott M, Liu L. (2004) Identification of two novel markers for alveolar epithelial type I and II cells. Biochem Biophys Res Commun, 319 (3): 774-80. [PMID:15184050]

2. Fujii E, Mellon SH. (2001) Regulation of uterine gamma-aminobutyric acid(A) receptor subunit expression throughout pregnancy. Endocrinology, 142 (5): 1770-7. [PMID:11316740]

3. Hedblom E, Kirkness EF. (1997) A novel class of GABAA receptor subunit in tissues of the reproductive system. J Biol Chem, 272 (24): 15346-50. [PMID:9182563]

4. Hood HM, Metten P, Crabbe JC, Buck KJ. (2006) Fine mapping of a sedative-hypnotic drug withdrawal locus on mouse chromosome 11. Genes Brain Behav, 5 (1): 1-10. [PMID:16436183]

5. Johnson SK, Haun RS. (2005) The gamma-aminobutyric acid A receptor pi subunit is overexpressed in pancreatic adenocarcinomas. JOP, 6 (2): 136-42. [PMID:15767729]

6. Neelands TR, Zhang J, Macdonald RL. (1999) GABA(A) receptors expressed in undifferentiated human teratocarcinoma NT2 cells differ from those expressed by differentiated NT2-N cells. J Neurosci, 19 (16): 7057-65. [PMID:10436060]

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