sialic acid binding Ig like lectin 8 | Sialic acid binding Ig like lectins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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sialic acid binding Ig like lectin 8

Target id: 3012

Nomenclature: sialic acid binding Ig like lectin 8

Abbreviated Name: SIGLEC8

Family: Sialic acid binding Ig like lectins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     sialic acid binding Ig like lectin 8 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 499 19q13.33-q13.41 SIGLEC8 sialic acid binding Ig like lectin 8
Mouse 1 569 7 B3 Siglecf sialic acid binding Ig-like lectin F
Rat 1 - 1q22 Siglec8 sialic acid binding Ig-like lectin 8
Previous and Unofficial Names
SAF2 | SIGLEC-8 | SIGLEC8L
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
General Comments
SSIGLEC8 is an I-type lectin that is expressed only on human eosinophils, basophils, mast cells [5]. It is an inhibitory receptor that engages sialoglycan ligands to diminish ongoing inflammation.

References

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1. Bochner BS. (2016) "Siglec"ting the allergic response for therapeutic targeting. Glycobiology, 26 (6): 546-52. [PMID:26911285]

2. FDA. humanized non-fucosylated anti-siglec-8 monoclonal antibody (IgG1). Accessed on 02/07/2018. Modified on 02/07/2018. US FDA Orphan Drug Designations and Approvals, https://www.accessdata.fda.gov/scripts/opdlisting/oopd/detailedIndex.cfm?cfgridkey=628417

3. Floyd H, Ni J, Cornish AL, Zeng Z, Liu D, Carter KC, Steel J, Crocker PR. (2000) Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily. J. Biol. Chem., 275 (2): 861-6. [PMID:10625619]

4. Jia Y, Yu H, Fernandes SM, Wei Y, Gonzalez-Gil A, Motari MG, Vajn K, Stevens WW, Peters AT, Bochner BS et al.. (2015) Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells. J. Allergy Clin. Immunol., 135 (3): 799-810.e7. [PMID:25747723]

5. Kikly KK, Bochner BS, Freeman SD, Tan KB, Gallagher KT, D'alessio KJ, Holmes SD, Abrahamson JA, Erickson-Miller CL, Murdock PR et al.. (2000) Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils. J. Allergy Clin. Immunol., 105 (6 Pt 1): 1093-100. [PMID:10856141]

6. Kiwamoto T, Kawasaki N, Paulson JC, Bochner BS. (2012) Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions. Pharmacol. Ther., 135 (3): 327-36. [PMID:22749793]

7. Schleimer RP, Schnaar RL, Bochner BS. (2016) Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression. Curr Opin Allergy Clin Immunol, 16 (1): 24-30. [PMID:26694037]

How to cite this page

Sialic acid binding Ig like lectins: sialic acid binding Ig like lectin 8. Last modified on 02/07/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=3012.