Fc fragment of IgM receptor | Immunoglobulin like domain containing proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

Top ▲

Fc fragment of IgM receptor

Target id: 2992

Nomenclature: Fc fragment of IgM receptor

Abbreviated Name: FcμRI

Family: Immunoglobulin like domain containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Fc fragment of IgM receptor has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 390 1q32.1 FCMR Fc fragment of IgM receptor 3
Mouse 1 422 1 E4 Fcmr Fc fragment of IgM receptor
Rat 1 426 13q13 Fcmr Fc fragment of IgM receptor
Gene and Protein Information Comments
Three alternate transcripts translating to two protein variants are reported for human FCMR.
Previous and Unofficial Names
FAIM3 | Fas apoptotic inhibitory molecule 3 | TOSO
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein


Show »

1. Hancer VS, Diz-Kucukkaya R, Aktan M. (2012) Overexpression of Fc mu receptor (FCMR, TOSO) gene in chronic lymphocytic leukemia patients. Med. Oncol., 29 (2): 1068-72. [PMID:21264533]

2. Hitoshi Y, Lorens J, Kitada SI, Fisher J, LaBarge M, Ring HZ, Francke U, Reed JC, Kinoshita S, Nolan GP. (1998) Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity, 8 (4): 461-71. [PMID:9586636]

3. Kubagawa H, Carroll MC, Jacob CO, Lang KS, Lee KH, Mak T, McAndrews M, Morse 3rd HC, Nolan GP, Ohno H et al.. (2015) Nomenclature of Toso, Fas apoptosis inhibitory molecule 3, and IgM FcR. J. Immunol., 194 (9): 4055-7. [PMID:25888699]

4. Lloyd KA, Wang J, Urban BC, Czajkowsky DM, Pleass RJ. (2017) Glycan-independent binding and internalization of human IgM to FCMR, its cognate cellular receptor. Sci Rep, 7: 42989. [PMID:28230186]

5. Pallasch CP, Schulz A, Kutsch N, Schwamb J, Hagist S, Kashkar H, Ultsch A, Wickenhauser C, Hallek M, Wendtner CM. (2008) Overexpression of TOSO in CLL is triggered by B-cell receptor signaling and associated with progressive disease. Blood, 112 (10): 4213-9. [PMID:18708628]

6. Proto-Siqueira R, Panepucci RA, Careta FP, Lee A, Clear A, Morris K, Owen C, Rizzatti EG, Silva Jr WA, Falc√£o RP et al.. (2008) SAGE analysis demonstrates increased expression of TOSO contributing to Fas-mediated resistance in CLL. Blood, 112 (2): 394-7. [PMID:18434611]

7. Richter GH, Mollweide A, Hanewinkel K, Zobywalski C, Burdach S. (2009) CD25 blockade protects T cells from activation-induced cell death (AICD) via maintenance of TOSO expression. Scand. J. Immunol., 70 (3): 206-15. [PMID:19703010]

8. Shima H, Takatsu H, Fukuda S, Ohmae M, Hase K, Kubagawa H, Wang JY, Ohno H. (2010) Identification of TOSO/FAIM3 as an Fc receptor for IgM. Int. Immunol., 22 (3): 149-56. [PMID:20042454]

9. Song Y, Jacob CO. (2005) The mouse cell surface protein TOSO regulates Fas/Fas ligand-induced apoptosis through its binding to Fas-associated death domain. J. Biol. Chem., 280 (10): 9618-26. [PMID:15632112]

10. Wang H, Coligan JE, Morse 3rd HC. (2016) Emerging Functions of Natural IgM and Its Fc Receptor FCMR in Immune Homeostasis. Front Immunol, 7: 99. [PMID:27014278]

How to cite this page

Immunoglobulin like domain containing proteins: Fc fragment of IgM receptor. Last modified on 06/03/2018. Accessed on 19/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2992.