tripartite motif containing 38 | 2.3.2.27 RING-type E3 ubiquitin transferase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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tripartite motif containing 38

Target id: 2984

Nomenclature: tripartite motif containing 38

Systematic Nomenclature: TRIM38

Family: 2.3.2.27 RING-type E3 ubiquitin transferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     tripartite motif containing 38 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 465 6p22.2 TRIM38 tripartite motif containing 38
Mouse - 471 13 A3.1 Trim38 tripartite motif-containing 38
Rat - - 17p11 Trim38 tripartite motif containing 38
Previous and Unofficial Names
ring finger protein 15 | RNF15 | RORET | tripartite motif-containing 38
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.3.2.27
Description Reaction Reference
Transfer of ubiquitin to L-lysine residue of the acceptor protein. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
General Comments
TRIM38 is an E3 ubiquitin ligase. It is required for innate immune response initiation upon detection of viral RNA or DNA by dedicated sensors [1].

References

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1. Hu MM, Shu HB. (2017) Multifaceted roles of TRIM38 in innate immune and inflammatory responses. Cell. Mol. Immunol., 14 (4): 331-338. [PMID:28194022]

2. Xue Q, Zhou Z, Lei X, Liu X, He B, Wang J, Hung T. (2012) TRIM38 negatively regulates TLR3-mediated IFN-β signaling by targeting TRIF for degradation. PLoS ONE, 7 (10): e46825. [PMID:23056470]

How to cite this page

2.3.2.27 RING-type E3 ubiquitin transferase: tripartite motif containing 38. Last modified on 05/02/2018. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2984.