leukocyte immunoglobulin like receptor B1 (CD85j) | Other immune checkpoint proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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leukocyte immunoglobulin like receptor B1 (CD85j)

Target id: 2973

Nomenclature: leukocyte immunoglobulin like receptor B1 (CD85j)

Abbreviated Name: LILRB1

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     leukocyte immunoglobulin like receptor B1 (CD85j) has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 650 19q13.42 LILRB1 leukocyte immunoglobulin like receptor B1
Gene and Protein Information Comments
Multiple transcript variants encoding different isoforms have been found for the human gene. We provide the RefSeqs and gene/protein information for isoform 1.
Previous and Unofficial Names
ILT2 | leucocyte Ig-like receptor B1 | leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 | LIR-1 | LIR1 | MIR-7 | myeloid inhibitory receptor 7 | PIR-B | PIRB
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Clinically-Relevant Mutations and Pathophysiology
Disease:  Multiple myeloma
Description: A myeloma that is located in the plasma cells in bone marrow.
Synonyms: plasma cell myeloma
Disease Ontology: DOID:9538
OMIM: 254500
Role: 
References:  5
General Comments
LILRB1 binds to MHC class I molecules on human lymphoid and myelomonocytic cells, including natural killer (NK) cells,T cells, B cells, monocytes, macrophages, and dendritic cells [4]. This interaction mediates an inhibitory 'don't-eat-me' signal via cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) contained in the protein's intracellular domain, and this inhibits propagation of an immune response upon recognition of self-MHC class I molecules.

References

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1. Barkal AA, Weiskopf K, Kao KS, Gordon SR, Rosental B, Yiu YY, George BM, Markovic M, Ring NG, Tsai JM et al.. (2018) Engagement of MHC class I by the inhibitory receptor LILRB1 suppresses macrophages and is a target of cancer immunotherapy. Nat. Immunol., 19 (1): 76-84. [PMID:29180808]

2. Burshtyn DN, Morcos C. (2016) The Expanding Spectrum of Ligands for Leukocyte Ig-like Receptors. J. Immunol., 196 (3): 947-55. [PMID:26802060]

3. Cheng Q, Cloonan N, Fischer K, Thompson J, Waine G, Lanzer M, Saul A. (1998) stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens. Mol. Biochem. Parasitol., 97 (1-2): 161-76. [PMID:9879895]

4. Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M. (1997) A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med., 186 (11): 1809-18. [PMID:9382880]

5. Lozano E, Díaz T, Mena MP, Suñe G, Calvo X, Calderón M, Pérez-Amill L, Rodríguez V, Pérez-Galán P, Roué G et al.. (2018) Loss of the Immune Checkpoint CD85j/LILRB1 on Malignant Plasma Cells Contributes to Immune Escape in Multiple Myeloma. J. Immunol., 200 (8): 2581-2591. [PMID:29531171]

6. Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S et al.. (2017) Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Nature, 552 (7683): 101-105. [PMID:29186116]

How to cite this page

Other immune checkpoint proteins: leukocyte immunoglobulin like receptor B1 (CD85j). Last modified on 15/05/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2973.