tripartite motif containing 21 | 2.3.2.27 RING-type E3 ubiquitin transferase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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tripartite motif containing 21

Target id: 2967

Nomenclature: tripartite motif containing 21

Family: 2.3.2.27 RING-type E3 ubiquitin transferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     tripartite motif containing 21 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 475 11p15.5-p15.3 TRIM21 tripartite motif containing 21
Mouse - 462 7 E3 Trim21 tripartite motif-containing 21
Rat - 471 1q32 Trim21 tripartite motif-containing 21
Previous and Unofficial Names
RNF81 | RO52 | Ro/SSA | Sjogren syndrome antigen A1 | SSA1
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  X-ray structure of the PRYSPRY domain of TRIM21 and IgG Fc domain.
PDB Id:  2IWG
Resolution:  2.35Å
Species:  Human
References:  3
Enzyme Reaction
EC Number: 2.3.2.27
Description Reaction Reference
Direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to acceptor protein. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine

References

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1. Agmon-Levin N, Dagan A, Peri Y, Anaya JM, Selmi C, Tincani A, Bizzaro N, Stojanovich L, Damoiseaux J, Cohen Tervaert JW et al.. (2017) The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic. Clin. Exp. Rheumatol., 35 (6): 929-935. [PMID:28770708]

2. Foss S, Watkinson R, Sandlie I, James LC, Andersen JT. (2015) TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity. Immunol. Rev., 268 (1): 328-39. [PMID:26497531]

3. James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J. (2007) Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc. Natl. Acad. Sci. U.S.A., 104 (15): 6200-5. [PMID:17400754]

4. Novak GV, Marques M, Balbi V, Gormezano NW, Kozu K, Sakamoto AP, Pereira RM, Terreri MT, Magalhães CS, Guariento A et al.. (2017) Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus. Autoimmun Rev, 16 (2): 132-135. [PMID:27988434]

5. Oke V, Wahren-Herlenius M. (2012) The immunobiology of Ro52 (TRIM21) in autoimmunity: a critical review. J. Autoimmun., 39 (1-2): 77-82. [PMID:22402340]

6. Ozato K, Shin DM, Chang TH, Morse 3rd HC. (2008) TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol., 8 (11): 849-60. [PMID:18836477]

7. Rajsbaum R, García-Sastre A, Versteeg GA. (2014) TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J. Mol. Biol., 426 (6): 1265-84. [PMID:24333484]

8. Versteeg GA, Benke S, García-Sastre A, Rajsbaum R. (2014) InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins. Cytokine Growth Factor Rev., 25 (5): 563-76. [PMID:25172371]

9. Zhou G, Wu W, Yu L, Yu T, Yang W, Wang P, Zhang X, Cong Y, Liu Z. (2017) Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting TH1/TH17 cell differentiation in patients with inflammatory bowel diseases. J. Allergy Clin. Immunol., [Epub ahead of print]. [PMID:29113905]

How to cite this page

2.3.2.27 RING-type E3 ubiquitin transferase: tripartite motif containing 21. Last modified on 13/11/2017. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2967.