tripartite motif containing 21 | RING-type E3 ubiquitin transferase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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tripartite motif containing 21

Target id: 2967

Nomenclature: tripartite motif containing 21

Family: RING-type E3 ubiquitin transferase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     tripartite motif containing 21 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 475 11p15.5-p15.3 TRIM21 tripartite motif containing 21
Mouse - 462 7 E3 Trim21 tripartite motif-containing 21
Rat - 471 1q32 Trim21 tripartite motif-containing 21
Previous and Unofficial Names
RNF81 | RO52 | Ro/SSA | Sjogren syndrome antigen A1 | SSA1
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  X-ray structure of the PRYSPRY domain of TRIM21 and IgG Fc domain.
Resolution:  2.35Å
Species:  Human
References:  3
Enzyme Reaction
EC Number:
Description Reaction Reference
Direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to acceptor protein. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine


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1. Agmon-Levin N, Dagan A, Peri Y, Anaya JM, Selmi C, Tincani A, Bizzaro N, Stojanovich L, Damoiseaux J, Cohen Tervaert JW et al.. (2017) The interaction between anti-Ro/SSA and anti-La/SSB autoantibodies and anti-infectious antibodies in a wide spectrum of auto-immune diseases: another angle of the autoimmune mosaic. Clin. Exp. Rheumatol., 35 (6): 929-935. [PMID:28770708]

2. Foss S, Watkinson R, Sandlie I, James LC, Andersen JT. (2015) TRIM21: a cytosolic Fc receptor with broad antibody isotype specificity. Immunol. Rev., 268 (1): 328-39. [PMID:26497531]

3. James LC, Keeble AH, Khan Z, Rhodes DA, Trowsdale J. (2007) Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function. Proc. Natl. Acad. Sci. U.S.A., 104 (15): 6200-5. [PMID:17400754]

4. Novak GV, Marques M, Balbi V, Gormezano NW, Kozu K, Sakamoto AP, Pereira RM, Terreri MT, Magalhães CS, Guariento A et al.. (2017) Anti-RO/SSA and anti-La/SSB antibodies: Association with mild lupus manifestations in 645 childhood-onset systemic lupus erythematosus. Autoimmun Rev, 16 (2): 132-135. [PMID:27988434]

5. Oke V, Wahren-Herlenius M. (2012) The immunobiology of Ro52 (TRIM21) in autoimmunity: a critical review. J. Autoimmun., 39 (1-2): 77-82. [PMID:22402340]

6. Ozato K, Shin DM, Chang TH, Morse 3rd HC. (2008) TRIM family proteins and their emerging roles in innate immunity. Nat. Rev. Immunol., 8 (11): 849-60. [PMID:18836477]

7. Rajsbaum R, García-Sastre A, Versteeg GA. (2014) TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J. Mol. Biol., 426 (6): 1265-84. [PMID:24333484]

8. Versteeg GA, Benke S, García-Sastre A, Rajsbaum R. (2014) InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins. Cytokine Growth Factor Rev., 25 (5): 563-76. [PMID:25172371]

9. Zhou G, Wu W, Yu L, Yu T, Yang W, Wang P, Zhang X, Cong Y, Liu Z. (2017) Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting TH1/TH17 cell differentiation in patients with inflammatory bowel diseases. J. Allergy Clin. Immunol., [Epub ahead of print]. [PMID:29113905]

How to cite this page RING-type E3 ubiquitin transferase: tripartite motif containing 21. Last modified on 13/11/2017. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,