Piezo1 | Piezo channels | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 2945

Nomenclature: Piezo1

Family: Piezo channels

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Piezo1 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2521 16q24.3 PIEZO1 piezo type mechanosensitive ion channel component 1
Mouse - 2547 8 E1 Piezo1 piezo-type mechanosensitive ion channel component 1
Rat - 2535 19q12 Piezo1 piezo-type mechanosensitive ion channel component 1
Gene and Protein Information Comments
Piezo proteins have between 24 and 36 predicted transmembrane (TM) domains, although a much lower number (14) of TM domains are resolved in the Piezo1 structure than initially predicted through topology software [1].
Previous and Unofficial Names
FAM38A | family with sequence similarity 38, member A | DHS | Mib | LMPH3
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Cryo-EM study of the mammalian mechanosensitive Piezo1 channel
Resolution:  4.8Å
Species:  Mouse
References:  2


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1. Coste B, Murthy SE, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A. (2015) Piezo1 ion channel pore properties are dictated by C-terminal region. Nat Commun, 6: 7223. [PMID:26008989]

2. Ge J, Li W, Zhao Q, Li N, Chen M, Zhi P, Li R, Gao N, Xiao B, Yang M. (2015) Architecture of the mammalian mechanosensitive Piezo1 channel. Nature, 527 (7576): 64-9. [PMID:26390154]

3. Liu CSC, Raychaudhuri D, Paul B, Chakrabarty Y, Ghosh AR, Rahaman O, Talukdar A, Ganguly D. (2018) Cutting Edge: Piezo1 Mechanosensors Optimize Human T Cell Activation. J. Immunol., 200 (4): 1255-1260. [PMID:29330322]

How to cite this page

Piezo channels: Piezo1. Last modified on 13/09/2018. Accessed on 19/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2945.