TIGIT | Other immune checkpoint proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 2941

Nomenclature: TIGIT

Family: Other immune checkpoint proteins, Immunoglobulin like domain containing proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     TIGIT has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 244 3q13.31 TIGIT T cell immunoreceptor with Ig and ITIM domains 2
Mouse 1 241 16 B4 Tigit T cell immunoreceptor with Ig and ITIM domains
Rat - - 11q21 Tigit T cell immunoreceptor with Ig and ITIM domains
Previous and Unofficial Names
T-cell immunoreceptor with Ig and ITIM domains | V-set and immunoglobulin domain containing 9 | V-set and transmembrane domain containing 3 | VSIG9 | VSTM3 | WUCAM [1]
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
General Comments
TIGIT was originally identified as a high affinity binding partner of the poliovirus receptor (PVR; P15151). TIGIT-PVR interaction promotes the generation of mature immunoregulatory dendritic cells and leads to suppression of T cell activation.


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1. Boles KS, Vermi W, Facchetti F, Fuchs A, Wilson TJ, Diacovo TG, Cella M, Colonna M. (2009) A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC. Eur. J. Immunol., 39 (3): 695-703. [PMID:19197944]

2. Yu X, Harden K, Gonzalez LC, Francesco M, Chiang E, Irving B, Tom I, Ivelja S, Refino CJ, Clark H et al.. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat. Immunol., 10 (1): 48-57. [PMID:19011627]

How to cite this page

Other immune checkpoint proteins: TIGIT. Last modified on 30/01/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2941.