TIM3 (CD366) | Other immune checkpoint proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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TIM3 (CD366)

Target id: 2940

Nomenclature: TIM3 (CD366)

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     TIM3 (CD366) has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 301 5q33.3 HAVCR2 hepatitis A virus cellular receptor 2 3
Mouse 1 281 11 B1.1 Havcr2 hepatitis A virus cellular receptor 2
Rat 1 282 10q21 Havcr2 hepatitis A virus cellular receptor 2
Previous and Unofficial Names
T-cell immunoglobulin mucin family member 3 | TIM-3 | TIMD-3
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Natural/Endogenous Ligands
galectin 9 {Sp: Human}
General Comments
The C-type lectin galectin-9 is a TIM3 ligand [1].


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1. Anderson AC. (2014) Tim-3: an emerging target in the cancer immunotherapy landscape. Cancer Immunol Res, 2 (5): 393-8. [PMID:24795351]

2. Koyama S, Akbay EA, Li YY, Herter-Sprie GS, Buczkowski KA, Richards WG, Gandhi L, Redig AJ, Rodig SJ, Asahina H et al.. (2016) Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. Nat Commun, 7: 10501. [PMID:26883990]

3. Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA et al.. (2002) Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature, 415 (6871): 536-41. [PMID:11823861]

4. Romero D. (2016) Immunotherapy: PD-1 says goodbye, TIM-3 says hello. Nat Rev Clin Oncol, 13 (4): 202-3. [PMID:26977783]

How to cite this page

Other immune checkpoint proteins: TIM3 (CD366). Last modified on 08/06/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2940.