C-type lectin domain family 4 member E | C-type lectin-like receptors (CLRs) | IUPHAR Guide to IMMUNOPHARMACOLOGY

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C-type lectin domain family 4 member E

Target id: 2929

Nomenclature: C-type lectin domain family 4 member E

Abbreviated Name: Mincle

Family: C-type lectin-like receptors (CLRs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     C-type lectin domain family 4 member E has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 219 12p13.31 CLEC4E C-type lectin domain family 4 member E
Mouse 1 214 C6, 58.35 cM, cytoband F3 Clec4e C-type lectin domain family 4, member e
Rat 1 2150 4q42 Clec4e C-type lectin domain family 4, member E
Previous and Unofficial Names
CLECSF9 | C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 9 | Macrophage-inducible C-type lectin | C-type lectin domain family 4, member E | C-type lectin domain family 4, member e | C-type lectin domain family 4
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Agonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GlcC14C18 Hs Agonist ~10.0 pEC50 2
pEC50 ~10.0 (EC50 ~1x10-10 M) [2]
Description: Measuring activation of an NF-κB reporter in HEK293 cells expressing human mincle.
General Comments
Mincle is a small type II membrane receptor with an extracellular C-type lectin-like domain and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM).

References

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1. Bryant CE, Orr S, Ferguson B, Symmons MF, Boyle JP, Monie TP. (2015) International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease. Pharmacol. Rev., 67 (2): 462-504. [PMID:25829385]

2. Decout A, Silva-Gomes S, Drocourt D, Barbe S, André I, Cueto FJ, Lioux T, Sancho D, Pérouzel E, Vercellone A et al.. (2017) Rational design of adjuvants targeting the C-type lectin Mincle. Proc. Natl. Acad. Sci. U.S.A., 114 (10): 2675-2680. [PMID:28223515]

3. Kawata K, Illarionov P, Yang GX, Kenny TP, Zhang W, Tsuda M, Ando Y, Leung PS, Ansari AA, Eric Gershwin M. (2012) Mincle and human B cell function. J. Autoimmun., 39 (4): 315-22. [PMID:22698596]

How to cite this page

C-type lectin-like receptors (CLRs): C-type lectin domain family 4 member E. Last modified on 16/05/2017. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2929.