DExD/H-box helicase 58 | RIG-I-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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DExD/H-box helicase 58

Target id: 2920

Nomenclature: DExD/H-box helicase 58

Abbreviated Name: RIG-1

Family: RIG-I-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     DExD/H-box helicase 58 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 925 9p21.1 DDX58 DExD/H-box helicase 58
Mouse - 926 4 A5 Ddx58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Rat - 598 5q22 Ddx58 DEXD/H-box helicase 58
Previous and Unofficial Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | retinoic acid inducible gene I | RNA helicase RIG-I
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Description Reaction Reference
RNA helicase: uses the energy from ATP hydrolysis to unwind RNA ATP + H(2)O <=> ADP + phosphate
Physiological Consequences of Altering Gene Expression
Conventional dendritic cells (cDCs), macrophages and fibroblasts isolated from RIG-1 null mice have impaired IFN induction after RNA virus infection. Plasmacytoid DCs are unaffected by RIG-1 knockout, suggesting nucleic acid sensing TLRs are more relevant in these cells.
Species:  Mouse
Tissue:  cDCs, macrophages and fibroblasts,


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1. Matsumiya T, Stafforini DM. (2010) Function and regulation of retinoic acid-inducible gene-I. Crit. Rev. Immunol., 30 (6): 489-513. [PMID:21175414]

How to cite this page

RIG-I-like receptor family: DExD/H-box helicase 58. Last modified on 07/02/2018. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,