CD300a | CD molecules | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 2918

Nomenclature: CD300a

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD300a has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 299 17q25.1 CD300A CD300a molecule 10
Mouse 1 318 11 E2; 11 80.54 cM Cd300a CD300A molecule
Rat 1 310 10q32.1 Cd300a Cd300a molecule
Gene and Protein Information Comments
The human RefSeq links here refer to IRC1a (the longest transcript giving rise to protein isoform 1). A shorter isoform 2 (IRC1c) has also been identified.
Previous and Unofficial Names
CMRF-35-H9 | Irp60 | LMIR1 (mouse) | CLM-8 | IGSF12
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein


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1. A-González N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. Biochim. Biophys. Acta, 1812 (8): 982-94. [PMID:21193033]

2. Alvarez Y, Tang X, Coligan JE, Borrego F. (2008) The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling. Mol. Immunol., 45 (1): 253-8. [PMID:17588661]

3. Bachelet I, Munitz A, Berent-Maoz B, Mankuta D, Levi-Schaffer F. (2008) Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a. J. Immunol., 180 (9): 6064-9. [PMID:18424727]

4. Bachelet I, Munitz A, Levi-Schaffer F. (2006) Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J. Allergy Clin. Immunol., 117 (6): 1314-20. [PMID:16750992]

5. Bachelet I, Munitz A, Moretta A, Moretta L, Levi-Schaffer F. (2005) The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J. Immunol., 175 (12): 7989-95. [PMID:16339535]

6. Borrego F. (2013) The CD300 molecules: an emerging family of regulators of the immune system. Blood, 121 (11): 1951-60. [PMID:23293083]

7. Cantoni C, Bottino C, Augugliaro R, Morelli L, Marcenaro E, Castriconi R, Vitale M, Pende D, Sivori S, Millo R et al.. (1999) Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells. Eur. J. Immunol., 29 (10): 3148-59. [PMID:10540326]

8. Clark GJ, Green BJ, Hart DN. (2000) The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17. Tissue Antigens, 55 (2): 101-9. [PMID:10746781]

9. Clark GJ, Rao M, Ju X, Hart DN. (2007) Novel human CD4+ T lymphocyte subpopulations defined by CD300a/c molecule expression. J. Leukoc. Biol., 82 (5): 1126-35. [PMID:17702825]

10. Green BJ, Clark GJ, Hart DN. (1998) The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor. Int. Immunol., 10 (7): 891-9. [PMID:9701027]

11. Ju X, Zenke M, Hart DN, Clark GJ. (2008) CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands. Blood, 112 (4): 1184-94. [PMID:18535206]

12. Kim EJ, Lee SM, Suk K, Lee WH. (2012) CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines. Immunology, 135 (3): 226-35. [PMID:22043923]

13. Munitz A, Bachelet I, Eliashar R, Moretta A, Moretta L, Levi-Schaffer F. (2006) The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils. Blood, 107 (5): 1996-2003. [PMID:16254138]

14. Narayanan S, Silva R, Peruzzi G, Alvarez Y, Simhadri VR, Debell K, Coligan JE, Borrego F. (2010) Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin. PLoS ONE, 5 (5): e10636. [PMID:20498708]

15. Zenarruzabeitia O, VitallĂ© J, Eguizabal C, Simhadri VR, Borrego F. (2015) The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine. J. Immunol., 194 (11): 5053-60. [PMID:25980030]

How to cite this page

CD molecules: CD300a. Last modified on 16/05/2017. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,