CD6 | CD molecules | IUPHAR Guide to IMMUNOPHARMACOLOGY

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CD6

Target id: 2917

Nomenclature: CD6

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD6 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 668 11q12.2 CD6 CD6 molecule
Mouse 1 665 19, 7.16 cM Cd6 CD6 antigen
Rat - 665 1q43 Cd6 Cd6 molecule
Gene and Protein Information Comments
Details of alternate transcripts and protein isoforms identified for human and mouse CD6 are available from their NCBI (Entrez) gene entries.
Previous and Unofficial Names
Tp120
Database Links
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
itolizumab Hs Binding 7.2 pKi 1
pKi 7.2 (Ki 6x10-8 M) [1]

References

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1. Alonso R, Huerta V, de Leon J, Piedra P, Puchades Y, Guirola O, Chinea G, Montero E. (2008) Towards the definition of a chimpanzee and human conserved CD6 domain 1 epitope recognized by T1 monoclonal antibody. Hybridoma (Larchmt), 27 (4): 291-301. [PMID:18707547]

2. Nair P, Melarkode R, Rajkumar D, Montero E. (2010) CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction. Clin. Exp. Immunol., 162 (1): 116-30. [PMID:20726988]

How to cite this page

CD molecules: CD6. Last modified on 06/02/2017. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2917.