CD159a | CD molecules | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 2849

Nomenclature: CD159a

Abbreviated Name: NKG2A

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD159a has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 233 12p13 KLRC1 killer cell lectin like receptor C1 4
Mouse - 244 6 G1-2 Klrc1 killer cell lectin-like receptor subfamily C, member 1
Rat - 236 4q42 Klrc1 killer cell lectin like receptor C1
Previous and Unofficial Names
killer cell lectin-like receptor subfamily C | killer cell lectin-like receptor subfamily C, member 1 | NKG2-1/B activating NK receptor | NKG2-A
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
monalizumab Hs Binding ~10.6 pKd 1
pKd ~10.6 (Kd ~2.7x10-11 M) [1]


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1. Andre P, Blery M, Paturel C, Soulas C, Wagtmann N. (2016) Treatment regimens using anti-nkg2a antibodies. Patent number: WO2016041947. Assignee: Innate Pharma. Priority date: 16/09/2014. Publication date: 24/03/2016.

2. Derré L, Corvaisier M, Charreau B, Moreau A, Godefroy E, Moreau-Aubry A, Jotereau F, Gervois N. (2006) Expression and release of HLA-E by melanoma cells and melanocytes: potential impact on the response of cytotoxic effector cells. J. Immunol., 177 (5): 3100-7. [PMID:16920947]

3. Godal R, Bachanova V, Gleason M, McCullar V, Yun GH, Cooley S, Verneris MR, McGlave PB, Miller JS. (2010) Natural killer cell killing of acute myelogenous leukemia and acute lymphoblastic leukemia blasts by killer cell immunoglobulin-like receptor-negative natural killer cells after NKG2A and LIR-1 blockade. Biol. Blood Marrow Transplant., 16 (5): 612-21. [PMID:20139023]

4. Houchins JP, Yabe T, McSherry C, Bach FH. (1991) DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J. Exp. Med., 173 (4): 1017-20. [PMID:2007850]

5. Levy EM, Bianchini M, Von Euw EM, Barrio MM, Bravo AI, Furman D, Domenichini E, Macagno C, Pinsky V, Zucchini C et al.. (2008) Human leukocyte antigen-E protein is overexpressed in primary human colorectal cancer. Int. J. Oncol., 32 (3): 633-41. [PMID:18292941]

6. Mamessier E, Sylvain A, Thibult ML, Houvenaeghel G, Jacquemier J, Castellano R, Gonçalves A, André P, Romagné F, Thibault G et al.. (2011) Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity. J. Clin. Invest., 121 (9): 3609-22. [PMID:21841316]

7. Silva TG, Crispim JC, Miranda FA, Hassumi MK, de Mello JM, Simões RT, Souto F, Soares EG, Donadi EA, Soares CP. (2011) Expression of the nonclassical HLA-G and HLA-E molecules in laryngeal lesions as biomarkers of tumor invasiveness. Histol. Histopathol., 26 (12): 1487-97. [PMID:21972088]

How to cite this page

CD molecules: CD159a. Last modified on 08/02/2017. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,