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Target id: 2840

Nomenclature: CD74

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD74 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 296 5q32 CD74 CD74 molecule 2,4
Mouse 1 279 18 E1 Cd74 CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Rat 1 280 18q12.1 Cd74 CD74 molecule
Previous and Unofficial Names
HLA-DR-gamma | Ia-associated invariant chain | invariant polypeptide of major histocompatibility complex, class II antigen-associated | CD74 molecule, major histocompatibility complex, class II invariant chain | Cd74 molecule, major histocompatibility complex, class II invariant chain | CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) | CD74 antigen (invariant polypeptide of major histocompatibility complex
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
milatuzumab Hs Binding 9.3 pKd 7
pKd 9.3 (Kd 5x10-10 M) [7]


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1. A-Gonz├ílez N, Castrillo A. (2011) Liver X receptors as regulators of macrophage inflammatory and metabolic pathways. Biochim. Biophys. Acta, 1812 (8): 982-94. [PMID:21193033]

2. Claesson L, Larhammar D, Rask L, Peterson PA. (1983) cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure. Proc. Natl. Acad. Sci. U.S.A., 80 (24): 7395-9. [PMID:6324166]

3. Cresswell P. (1994) Assembly, transport, and function of MHC class II molecules. Annu. Rev. Immunol., 12: 259-93. [PMID:8011283]

4. Kudo J, Chao LY, Narni F, Saunders GF. (1985) Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens. Nucleic Acids Res., 13 (24): 8827-41. [PMID:3001652]

5. Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med., 197 (11): 1467-76. [PMID:12782713]

6. Matza D, Wolstein O, Dikstein R, Shachar I. (2001) Invariant chain induces B cell maturation by activating a TAF(II)105-NF-kappaB-dependent transcription program. J. Biol. Chem., 276 (29): 27203-6. [PMID:11371575]

7. Sapra P, Stein R, Pickett J, Qu Z, Govindan SV, Cardillo TM, Hansen HJ, Horak ID, Griffiths GL, Goldenberg DM. (2005) Anti-CD74 antibody-doxorubicin conjugate, IMMU-110, in a human multiple myeloma xenograft and in monkeys. Clin. Cancer Res., 11 (14): 5257-64. [PMID:16033844]

How to cite this page

CD molecules: CD74. Last modified on 15/05/2017. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,