CD86 | Other immune checkpoint proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 2745

Nomenclature: CD86

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD86 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 329 3q21 CD86 CD86 molecule
Mouse - 309 16 B5 Cd86 CD86 antigen
Rat - 313 11q22 Cd86 CD86 molecule
Previous and Unofficial Names
CD86 antigen
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
abatacept Hs Inhibition ~7.9 pKd 2-3
pKd ~7.9 (Kd ~1.2x10-8 M) [2-3]
Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept.
belatacept Hs Inhibition - - 1
Description: IC50= 0.120µg/mL


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1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med., 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

Other immune checkpoint proteins: CD86. Last modified on 03/01/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,