CD80 | Other immune checkpoint proteins | IUPHAR Guide to IMMUNOPHARMACOLOGY

Top ▲


Target id: 2744

Nomenclature: CD80

Family: Other immune checkpoint proteins, CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD80 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 288 3q13.3-q21 CD80 CD80 molecule
Mouse - 306 16 B5 Cd80 CD80 antigen
Rat - 321 11q21 Cd80 Cd80 molecule
Previous and Unofficial Names
B-lymphocyte activation antigen B7 | CD28LG | CD80 antigen
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
abatacept Hs Inhibition ~7.9 pKd 2-3
pKd ~7.9 (Kd ~1.2x10-8 M) [2-3]
Description: Measuring binding of 125I-labeled B7Ig fusion protein to immobilized abatacept.
belatacept Hs Inhibition - - 1
Description: IC50= 0.009µg/mL


Show »

1. Latek R, Fleener C, Lamian V, Kulbokas 3rd E, Davis PM, Suchard SJ, Curran M, Vincenti F, Townsend R. (2009) Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation. Transplantation, 87 (6): 926-33. [PMID:19300198]

2. Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. (1991) CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med., 174 (3): 561-9. [PMID:1714933]

3. Vicente Rabaneda EF, Herrero-Beaumont G, Castañeda S. (2013) Update on the use of abatacept for the treatment of rheumatoid arthritis. Expert Rev Clin Immunol, 9 (7): 599-621. [PMID:23899231]

How to cite this page

Other immune checkpoint proteins: CD80. Last modified on 12/07/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,