CD2 | CD molecules | IUPHAR Guide to IMMUNOPHARMACOLOGY

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CD2

Target id: 2600

Nomenclature: CD2

Family: CD molecules

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD2 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 351 1p13 CD2 CD2 molecule
Mouse - 344 3 F2.2 Cd2 CD2 antigen
Rat - 344 2q34 Cd2 Cd2 molecule
Database Links
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
alefacept Hs Inhibition - - 1-2
[1-2]

References

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1. da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS. (2002) Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J. Immunol., 168 (9): 4462-71. [PMID:11970990]

2. Mitchell P. (2002) First biotech drug to treat psoriasis. Nat. Biotechnol., 20 (7): 640-1. [PMID:12089534]

3. Yang JJ, Ye Y, Carroll A, Yang W, Lee HW. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr. Protein Pept. Sci., 2 (1): 1-17. [PMID:12369898]

How to cite this page

CD molecules: CD2. Last modified on 12/07/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2600.