integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor) | Integrins | IUPHAR Guide to IMMUNOPHARMACOLOGY

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integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Target id: 2443

Nomenclature: integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)

Family: Integrins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor) has curated data in GtoImmuPdb

Quaternary Structure: Complexes
integrin α4β1
integrin α4β7
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1032 2q31-q32 ITGA4 integrin subunit alpha 4
Mouse - 1039 2 C3 Itga4 integrin alpha 4
Rat - - 3q24 Itga4 integrin subunit alpha 4
Previous and Unofficial Names
CD49 antigen-like family member D | CD49D | integrin alpha-4 | lymphocyte Peyer patch adhesion molecules subunit alpha | integrin, alpha 4
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
natalizumab Hs Inhibition - - 2
[2]
Antibody Comments
Natalizumab targets heteromeric integrin receptors of which α4 is a subunit.

References

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1. Han J, Liu S, Rose DM, Schlaepfer DD, McDonald H, Ginsberg MH. (2001) Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. J. Biol. Chem., 276 (44): 40903-9. [PMID:11533025]

2. No authors listed. (2004) Natalizumab: AN 100226, anti-4alpha integrin monoclonal antibody. Drugs R D, 5 (2): 102-7. [PMID:15293871]

How to cite this page

Integrins: integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor). Last modified on 19/04/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2443.