cathepsin H | C1: Papain | IUPHAR Guide to IMMUNOPHARMACOLOGY

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cathepsin H

Target id: 2349

Nomenclature: cathepsin H

Family: C1: Papain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     cathepsin H has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 335 15q25.1 CTSH cathepsin H
Mouse - 333 9 E3.1 Ctsh cathepsin H
Rat - 333 8q31 Ctsh cathepsin H
Previous and Unofficial Names
ACC-4 | ACC-5 | cathepsin B3 | cathepsin BA | CPSB
Database Links
Specialist databases
MEROPS C01.040 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 1b [PMID: 16290936] Hs Inhibition 7.4 pKi 1
pKi 7.4 (Ki 4x10-8 M) [1]
compound 1e [PMID: 27285276] Hs Inhibition 6.4 pIC50 3
pIC50 6.4 (IC50 4.4x10-7 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Narcolepsy-cataplexy
Synonyms: Cataplexy and narcolepsy [Disease Ontology: DOID:9199]
Disease Ontology: DOID:9199
Orphanet: ORPHA2073


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1. Adkison KK, Barrett DG, Deaton DN, Gampe RT, Hassell AM, Long ST, McFadyen RB, Miller AB, Miller LR, Payne JA et al.. (2006) Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors?. Bioorg. Med. Chem. Lett., 16 (4): 978-83. [PMID:16290936]

2. D'Angelo ME, Bird PI, Peters C, Reinheckel T, Trapani JA, Sutton VR. (2010) Cathepsin H is an additional convertase of pro-granzyme B. J. Biol. Chem., 285 (27): 20514-9. [PMID:20435891]

3. Garg S, Raghav N. (2016) 2,5-Diaryloxadiazoles and their precursors as novel inhibitors of cathepsins B, H and L. Bioorg. Chem., 67: 64-74. [PMID:27285276]

4. Magister Š, Tseng HC, Bui VT, Kos J, Jewett A. (2015) Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F. Oncotarget, 6 (26): 22310-27. [PMID:26247631]

How to cite this page

C1: Papain: cathepsin H. Last modified on 21/04/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,