cathepsin G | S1: Chymotrypsin | IUPHAR Guide to IMMUNOPHARMACOLOGY

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cathepsin G

Target id: 2348

Nomenclature: cathepsin G

Family: S1: Chymotrypsin

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

This target is also described as a ligand entry: cathepsin Gcathepsin Gcathepsin G

   GtoImmuPdb view: ON :     cathepsin G has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 255 14q12 CTSG cathepsin G
Mouse - 261 14 C3 Ctsg cathepsin G
Rat - 250 15p12 Ctsg cathepsin G
Previous and Unofficial Names
vimentin-specific protease | VSP
Database Links
Specialist databases
MEROPS S01.133 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 1 [PMID: 11425539] Hs Inhibition 9.4 pIC50 1
pIC50 9.4 (IC50 3.9x10-10 M) [1]
compound 4g [PMID: 22595175] Hs Inhibition 4.8 pIC50 2
pIC50 4.8 (IC50 1.42x10-5 M) [2]


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1. Aoyama Y, Uenaka M, Konoike T, Hayasaki-Kajiwara Y, Naya N, Nakajima M. (2001) Inhibition of serine proteases: activity of 1,3-diazetidine-2,4-diones. Bioorg. Med. Chem. Lett., 11 (13): 1691-4. [PMID:11425539]

2. Santana AB, Lucas SD, Gonçalves LM, Correia HF, Cardote TA, Guedes RC, Iley J, Moreira R. (2012) N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg. Med. Chem. Lett., 22 (12): 3993-7. [PMID:22595175]

How to cite this page

S1: Chymotrypsin: cathepsin G. Last modified on 20/04/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,