cathepsin C | C1: Papain | IUPHAR Guide to IMMUNOPHARMACOLOGY

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cathepsin C

Target id: 2344

Nomenclature: cathepsin C

Family: C1: Papain

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     cathepsin C has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 463 11q14.2 CTSC cathepsin C
Mouse - 462 7 D3-E1.1 Ctsc cathepsin C
Rat - 462 1q32 Ctsc cathepsin C
Previous and Unofficial Names
CATC | cathepsin J | dipeptidyl peptidase 1 | dipeptidyl transferase | DPP1 | PALS | PLS
Database Links
Specialist databases
MEROPS C01.070 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.14.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
AZD7986 Hs Inhibition 8.6 pKd 1
pKd 8.6 (Kd 2.5x10-9 M) [1]
Description: Surface plasmon resonance direct binding assay
compound 3d [PMID: 3941405] Hs Inhibition 5.6 pKi 2
pKi 5.6 (Ki 2.7x10-6 M) [2]
AZD7986 Hs Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 3.98x10-9 M) [1]
Description: In vitro enzyme assay
AZD7986 Rn Inhibition 7.7 pIC50 1
pIC50 7.7 (IC50 1.99x10-8 M) [1]
Description: In vitro enzyme assay
AZD7986 Mm Inhibition 7.6 pIC50 1
pIC50 7.6 (IC50 2.51x10-8 M) [1]
Description: In vitro enzyme assay
View species-specific inhibitor tables
Clinically-Relevant Mutations and Pathophysiology
Disease:  Haim-Munk syndrome
OMIM: 245010
Orphanet: ORPHA2342
Disease:  Papillon-Lefevre syndrome
Synonyms: Papillon-Lefevre disease [Disease Ontology: DOID:3389]
Disease Ontology: DOID:3389
OMIM: 245000
Orphanet: ORPHA678
Disease:  Periodontitis, aggressive, 1
Synonyms: Aggressive periodontitis [Disease Ontology: DOID:1474]
Disease Ontology: DOID:1474
OMIM: 170650

References

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1. Doyle K, Lönn H, Käck H, Van de Poël A, Swallow S, Gardiner P, Connolly S, Root J, Wikell C, Dahl G et al.. (2016) Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986). J. Med. Chem., 59 (20): 9457-9472. [PMID:27690432]

2. Thompson SA, Andrews PR, Hanzlik RP. (1986) Carboxyl-modified amino acids and peptides as protease inhibitors. J. Med. Chem., 29 (1): 104-11. [PMID:3941405]

How to cite this page

C1: Papain: cathepsin C. Last modified on 02/12/2016. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2344.