cathepsin B | C1: Papain | IUPHAR Guide to IMMUNOPHARMACOLOGY

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cathepsin B

Target id: 2343

Nomenclature: cathepsin B

Family: C1: Papain

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: ON :     cathepsin B has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 339 8p23.1 CTSB cathepsin B
Mouse - 339 14 D1 Ctsb cathepsin B
Rat - 339 15p12 Ctsb cathepsin B
Previous and Unofficial Names
cathepsin B1 | CB | RSG-2
Database Links
Specialist databases
MEROPS C01.060 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
Z-Arg-Leu-Val-Agly-Ile-Val-OMe Hs Inhibition 10.1 pKi 2
pKi 10.1 (Ki 8.8x10-11 M) [2]
LHVS Hs Inhibition 5.9 pIC50 1
pIC50 5.9 (IC50 1.36x10-6 M) [1]

References

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1. Méthot N, Rubin J, Guay D, Beaulieu C, Ethier D, Reddy TJ, Riendeau D, Percival MD. (2007) Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J. Biol. Chem., 282 (29): 20836-46. [PMID:17535802]

2. Wieczerzak E, Drabik P, Łankiewicz L, Ołdziej S, Grzonka Z, Abrahamson M, Grubb A, Brömme D. (2002) Azapeptides structurally based upon inhibitory sites of cystatins as potent and selective inhibitors of cysteine proteases. J. Med. Chem., 45 (19): 4202-11. [PMID:12213061]

How to cite this page

C1: Papain: cathepsin B. Last modified on 21/04/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2343.