complement C1s | S1: Chymotrypsin | IUPHAR Guide to IMMUNOPHARMACOLOGY

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complement C1s

Target id: 2335

Nomenclature: complement C1s

Family: S1: Chymotrypsin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     complement C1s has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 688 12p13 C1S complement C1s
Mouse - 688 6 F2 C1s2 complement component 1, s subcomponent 2
Rat - 694 4q42 C1s complement C1s
Previous and Unofficial Names
C1sb | complement component C1SB | r-gsp | Gm5077 | predicted gene 5077 | complement component 1 | complement component 1, s subcomponent 2
Database Links
Specialist databases
MEROPS S01.193 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 28 [PMID: 16460935] Hs Inhibition 8.0 pKi 2
pKi 8.0 (Ki 1x10-8 M) [2]
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
TNT009 Hs Binding 9.6 pKd 1
pKd 9.6 (Kd 2.6x10-10 M) [1]
Antibody Comments
TNT009 binds to pro-C1s and mature C1s with the same affinity [1].
Clinically-Relevant Mutations and Pathophysiology
Disease:  Complement component C1s deficiency
Synonyms: Immunodeficiency due to an early component of complement deficiency [Orphanet: ORPHA169147]
OMIM: 613783
Orphanet: ORPHA169147


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1. Panicker S, Parry G. (2016) Humanized anti-c1s antibodies and methods of use thereof. Patent number: WO2016164358A1. Assignee: True North Therapeutics, Inc.. Priority date: 06/04/2015. Publication date: 05/04/2016.

2. Subasinghe NL, Travins JM, Ali F, Huang H, Ballentine SK, Marugán JJ, Khalil E, Hufnagel HR, Bone RF, DesJarlais RL et al.. (2006) A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. Bioorg. Med. Chem. Lett., 16 (8): 2200-4. [PMID:16460935]

How to cite this page

S1: Chymotrypsin: complement C1s. Last modified on 15/02/2018. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,