Interleukin 27 receptor, alpha | IL-6 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin 27 receptor, alpha

Target id: 2318

Nomenclature: Interleukin 27 receptor, alpha

Family: IL-6 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Interleukin 27 receptor, alpha has curated data in GtoImmuPdb

Quaternary Structure: Complexes
Interleukin-27 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 636 19p13.12 IL27RA interleukin 27 receptor subunit alpha
Mouse 1 623 8 C3 Il27ra interleukin 27 receptor, alpha
Rat - - 19q11 Il27ra interleukin 27 receptor subunit alpha
Previous and Unofficial Names
WSX-1 | cytokine receptor-like 1 | IL-27RA | TCCR | interleukin 27 receptor, alpha | interleukin 27 receptor
Database Links
CATH/Gene3D
Ensembl Gene
Human Protein Atlas
UniProtKB
Wikipedia
Physiological Consequences of Altering Gene Expression
MIce lacking Il27ra expression by their Treg cells develop more severe experimental autoimmune encephalomyelitis (EAE) than wild type mice, indicating that IL-27 is important for Treg function and control of autoimmunity.
Species:  Mouse
Tissue:  T regulatory cells.
Technique: 
References:  1

References

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1. Do J, Kim D, Kim S, Valentin-Torres A, Dvorina N, Jang E, Nagarajavel V, DeSilva TM, Li X, Ting AH et al.. (2017) Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity. Proc. Natl. Acad. Sci. U.S.A., 114 (38): 10190-10195. [PMID:28874534]

How to cite this page

IL-6 receptor family: Interleukin 27 receptor, alpha. Last modified on 18/09/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2318.