receptor interacting serine/threonine kinase 3 | Receptor interacting protein kinase (RIPK) family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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receptor interacting serine/threonine kinase 3

Target id: 2191

Nomenclature: receptor interacting serine/threonine kinase 3

Abbreviated Name: RIPK3

Family: Receptor interacting protein kinase (RIPK) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     receptor interacting serine/threonine kinase 3 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 518 14q12 RIPK3 receptor interacting serine/threonine kinase 3
Mouse - 486 14 C1 Ripk3 receptor-interacting serine-threonine kinase 3
Rat - 478 15 p13 Ripk3 receptor-interacting serine-threonine kinase 3
Previous and Unofficial Names
RIP3 | homocysteine respondent protein HCYP2 | RIP-like protein kinase 3
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Physiological Functions
RIPK3 is an essential regulator of TNF-induced necrosis.
Species:  Mouse
References:  1,3,12
Physiological Consequences of Altering Gene Expression
RIPK3 knockout mice are devoid of inflammation inflicted tissue damage in an acute pancreatitis model, and exhibit severely impaired virus-induced tissue necrosis, inflammation, and control of viral replication.
Species:  Mouse
Technique:  Gene knockout.
References:  1,3
Deletion of RIPK3 confers complete protection against lethal TNF-induced systemic inflammatory response syndrome (SIRS).
Species:  Mouse
Technique:  Gene knockout.
References:  2
General Comments
The role of RIPK3 as a critical regulator of programmed necrosis (necroptosis) is reviewed in [5].


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1. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK. (2009) Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell, 137 (6): 1112-23. [PMID:19524513]

2. Duprez L, Takahashi N, Van Hauwermeiren F, Vandendriessche B, Goossens V, Vanden Berghe T, Declercq W, Libert C, Cauwels A, Vandenabeele P. (2011) RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity, 35 (6): 908-18. [PMID:22195746]

3. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. (2009) Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell, 137 (6): 1100-11. [PMID:19524512]

4. Kopalli SR, Kang TB, Koppula S. (2016) Necroptosis inhibitors as therapeutic targets in inflammation mediated disorders - a review of the current literature and patents. Expert Opin Ther Pat, 26 (11): 1239-1256. [PMID:27568917]

5. Moriwaki K, Chan FK. (2013) RIP3: a molecular switch for necrosis and inflammation. Genes Dev., 27 (15): 1640-9. [PMID:23913919]

6. Najafov A, Chen H, Yuan J. (2017) Necroptosis and Cancer. Trends Cancer, 3 (4): 294-301. [PMID:28451648]

7. Rickard JA, O'Donnell JA, Evans JM, Lalaoui N, Poh AR, Rogers T, Vince JE, Lawlor KE, Ninnis RL, Anderton H et al.. (2014) RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell, 157 (5): 1175-88. [PMID:24813849]

8. Shlomovitz I, Zargrian S, Gerlic M. (2017) Mechanisms of RIPK3-induced inflammation. Immunol. Cell Biol., 95 (2): 166-172. [PMID:27974745]

9. Silke J, Rickard JA, Gerlic M. (2015) The diverse role of RIP kinases in necroptosis and inflammation. Nat. Immunol., 16 (7): 689-97. [PMID:26086143]

10. Vince JE, Silke J. (2016) The intersection of cell death and inflammasome activation. Cell. Mol. Life Sci., 73 (11-12): 2349-67. [PMID:27066895]

11. Wang T, Jin Y, Yang W, Zhang L, Jin X, Liu X, He Y, Li X. (2017) Necroptosis in cancer: An angel or a demon?. Tumour Biol., 39 (6): 1010428317711539. [PMID:28651499]

12. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. (2009) RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science, 325 (5938): 332-6. [PMID:19498109]

How to cite this page

Receptor interacting protein kinase (RIPK) family: receptor interacting serine/threonine kinase 3. Last modified on 09/01/2018. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,