interleukin 1 receptor associated kinase 2 | Interleukin-1 receptor-associated kinase (IRAK) family | IUPHAR Guide to IMMUNOPHARMACOLOGY

Top ▲

interleukin 1 receptor associated kinase 2

Target id: 2043

Nomenclature: interleukin 1 receptor associated kinase 2

Abbreviated Name: IRAK2

Family: Interleukin-1 receptor-associated kinase (IRAK) family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     interleukin 1 receptor associated kinase 2 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 625 3p25.2 IRAK2 interleukin 1 receptor associated kinase 2
Mouse - 622 6 E3 Irak2 interleukin-1 receptor-associated kinase 2
Rat - 624 4 q42 Irak2 interleukin-1 receptor-associated kinase 2
Previous and Unofficial Names
interleukin-1 receptor-associated kinase 2
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  The ternary Death Domain complex of MyD88, IRAK4, and IRAK2
PDB Id:  3MOP
Resolution:  3.4Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 2.7.11.1
General Comments
One of the proximal mediators of IL-1 signaling via the IL-1 receptor, plays a part in IL-1-induced upregulation of the transcription factor NF-κB, the other being IRAK1. Interacts with TRAF6 and Myd88.

References

Show »

1. Lin SC, Lo YC, Wu H. (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature, 465 (7300): 885-90. [PMID:20485341]

How to cite this page

Interleukin-1 receptor-associated kinase (IRAK) family: interleukin 1 receptor associated kinase 2. Last modified on 21/03/2017. Accessed on 19/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2043.