death receptor 3 | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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death receptor 3

Target id: 1883

Nomenclature: death receptor 3

Abbreviated Name: DR3

Systematic Nomenclature: TNFRSF25

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     death receptor 3 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 417 01p36.31 TNFRSF25 TNF receptor superfamily member 25
Mouse - - Tnfrsf25 tumor necrosis factor receptor superfamily, member 25
Rat - - Tnfrsf25 TNF receptor superfamily member 25
Previous and Unofficial Names
apoptosis-mediating receptor DR3 | apoptosis-mediating receptor TRAMP | death domain receptor 3 | WSL-1 | WSL-LR | tumor necrosis factor receptor superfamily, member 25 | APO-3 | DDR3 | TNFRSF12 | TR3 | tumor necrosis factor receptor superfamily
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Adaptor proteins (Human)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
TL1A {Sp: Human} Hs - - -


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1. Schreiber TH, Wolf D, Tsai MS, Chirinos J, Deyev VV, Gonzalez L, Malek TR, Levy RB, Podack ER. (2010) Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J. Clin. Invest., 120 (10): 3629-40. [PMID:20890040]


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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: death receptor 3. Last modified on 10/07/2018. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,