CD27 | Tumour necrosis factor (TNF) receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 1876

Nomenclature: CD27

Systematic Nomenclature: TNFRSF7

Family: Tumour necrosis factor (TNF) receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     CD27 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 260 12p13.31 CD27 CD27 molecule
Mouse 1 250 Cd27 CD27 antigen
Rat - - Cd27 CD27 molecule
Previous and Unofficial Names
CD antigen 27 | CD27 molecule | Tp55
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Adaptor proteins (Human)
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CD70 {Sp: Human} Hs - - -


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1. Buchan SL, Rogel A, Al-Shamkhani A. (2018) The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy. Blood, 131 (1): 39-48. [PMID:29118006]

2. van de Ven K, Borst J. (2015) Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential. Immunotherapy, 7 (6): 655-67. [PMID:26098609]


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How to cite this page

David MacEwan.
Tumour necrosis factor (TNF) receptor family: CD27. Last modified on 07/03/2018. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,