NLRC5 | NOD-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 1765

Nomenclature: NLRC5

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     NLRC5 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1866 16q13 NLRC5 NLR family CARD domain containing 5
Mouse - 1915 8 46.55 cM Nlrc5 NLR family, CARD domain containing 5
Previous and Unofficial Names
CLR16.1 | NOD27 | NOD4 | NOD-like receptor C5 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5 | NLR family, CARD domain containing 5 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Physiological Functions Comments
Transactivator of class I major histocompatibility complex genes.


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1. Cui J, Zhu L, Xia X, Wang HY, Legras X, Hong J, Ji J, Shen P, Zheng S, Chen ZJ et al.. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell, 141 (3): 483-96. [PMID:20434986]

2. Kuenzel S, Till A, Winkler M, Häsler R, Lipinski S, Jung S, Grötzinger J, Fickenscher H, Schreiber S, Rosenstiel P. (2010) The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses. J. Immunol., 184 (4): 1990-2000. [PMID:20061403]

3. Liu YR, Yan X, Yu HX, Yao Y, Wang JQ, Li XF, Chen RN, Xu QQ, Ma TT, Huang C et al.. (2017) NLRC5 promotes cell proliferation via regulating the NF-κB signaling pathway in Rheumatoid arthritis. Mol. Immunol., 91: 24-34. [PMID:28865311]

4. Neerincx A, Lautz K, Menning M, Kremmer E, Zigrino P, Hösel M, Büning H, Schwarzenbacher R, Kufer TA. (2010) A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses. J. Biol. Chem., 285 (34): 26223-32. [PMID:20538593]


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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: NLRC5. Last modified on 29/09/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,