NLRC3 | NOD-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 1764

Nomenclature: NLRC3

Family: NOD-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     NLRC3 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1065 16p13.3 NLRC3 NLR family CARD domain containing 3
Mouse - 1064 16 2.32 cM Nlrc3 NLR family, CARD domain containing 3
Rat - - 10 q12 Nlrc3 NLR family, CARD domain containing 3
Previous and Unofficial Names
CLR16.2 | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3 | NLR family, CARD domain containing 3 | Caterpiller 16.2 | NOD3 | NLR family
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Physiological Functions Comments
Negative regulation of inflammatory signalling.


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1. Mangan MS, Latz E. (2014) NLRC3 puts the brakes on STING. Immunity, 40 (3): 305-6. [PMID:24656040]

2. Zhang L, Mo J, Swanson KV, Wen H, Petrucelli A, Gregory SM, Zhang Z, Schneider M, Jiang Y, Fitzgerald KA et al.. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity, 40 (3): 329-41. [PMID:24560620]


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How to cite this page

Clare Bryant, Tom Monie.
NOD-like receptor family: NLRC3. Last modified on 13/04/2018. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,