TLR6 | Toll-like receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 1756

Nomenclature: TLR6

Family: Toll-like receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     TLR6 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 765 4p14 TLR6 toll like receptor 6
Mouse - 768 5 33.54 cM Tlr6 toll-like receptor 6
Rat - - 14p11 Tlr6 toll-like receptor 6
Previous and Unofficial Names
CD286 | toll-like receptor 6
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
Clinically-Relevant Mutations and Pathophysiology
Disease:  Aspergillosis
Disease Ontology: DOID:13564
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807


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1. Farhat K, Riekenberg S, Heine H, Debarry J, Lang R, Mages J, Buwitt-Beckmann U, Röschmann K, Jung G, Wiesmüller KH et al.. (2008) Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling. J. Leukoc. Biol., 83 (3): 692-701. [PMID:18056480]

2. Nakao Y, Funami K, Kikkawa S, Taniguchi M, Nishiguchi M, Fukumori Y, Seya T, Matsumoto M. (2005) Surface-expressed TLR6 participates in the recognition of diacylated lipopeptide and peptidoglycan in human cells. J. Immunol., 174 (3): 1566-73. [PMID:15661917]


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How to cite this page

Clare Bryant, Tom Monie.
Toll-like receptor family: TLR6. Last modified on 16/05/2017. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,