Eythropoietin receptor | Prolactin receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Eythropoietin receptor

Target id: 1718

Nomenclature: Eythropoietin receptor

Family: Prolactin receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Eythropoietin receptor has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 508 19p13.3-p13.2 EPOR erythropoietin receptor
Mouse 1 507 9 7.93 cM Epor erythropoietin receptor
Rat 1 507 8q13 Epor erythropoietin receptor
Previous and Unofficial Names
EPO-R | erythropoietin receptor
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human erythropoietin complexed to its receptor at 1.9 angstroms
Ligand:  erythropoietin
Resolution:  1.9Å
Species:  Human
References:  5

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
erythropoietin {Sp: Human} Hs Agonist 11.1 pIC50 3
pIC50 11.1 (IC50 7x10-12 M) [3]
Description: Assay performed using recombinant human EPO
peginesatide Hs Agonist 10.4 pIC50 3
pIC50 10.4 (IC50 3.7x10-11 M) [3]
cibinetide Hs Agonist - - 2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Erythrocytosis, familial, 1; ECYT1
Synonyms: Primary familial polycythemia [Orphanet: ORPHA90042]
OMIM: 133100
Orphanet: ORPHA90042
General Comments
The EPO/EPOR sytem is responsible for erythropoiesis and has an endogenous tissue protective role. The classical hematopoietic EPO receptor is a homodimer of two EPOR subunits. A non-hematopoietic EPOR-containing receptor, called the innate repair receptor (IRR) or tissue-protective receptor exists, and structurally this is a heterodimer composed of the EPOR and the cytokine receptor β common receptor subunit (CD131) [1].


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1. Brines M, Cerami A. (2012) The receptor that tames the innate immune response. Mol. Med., 18: 486-96. [PMID:22183892]

2. Cerami A, Brines M. (2009) Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage. Patent number: WO2009094172. Assignee: Araim Pharmaceuticals, Inc.. Priority date: 18/10/2017. Publication date: 22/01/2009.

3. Fan Q, Leuther KK, Holmes CP, Fong KL, Zhang J, Velkovska S, Chen MJ, Mortensen RB, Leu K, Green JM et al.. (2006) Preclinical evaluation of Hematide, a novel erythropoiesis stimulating agent, for the treatment of anemia. Exp. Hematol., 34 (10): 1303-11. [PMID:16982323]

4. Leist M, Ghezzi P, Grasso G, Bianchi R, Villa P, Fratelli M, Savino C, Bianchi M, Nielsen J, Gerwien J et al.. (2004) Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science, 305 (5681): 239-42. [PMID:15247477]

5. Syed RS, Reid SW, Li C, Cheetham JC, Aoki KH, Liu B, Zhan H, Osslund TD, Chirino AJ, Zhang J et al.. (1998) Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature, 395 (6701): 511-6. [PMID:9774108]

How to cite this page

Prolactin receptor family: Eythropoietin receptor. Last modified on 18/10/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1718.