Interleukin-7 receptor subunit α | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-7 receptor subunit α

Target id: 1698

Nomenclature: Interleukin-7 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Interleukin-7 receptor subunit α has curated data in GtoImmuPdb

Quaternary Structure: Complexes
Interleukin-7 receptor
Thymic stromal lymphopoietin receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 459 05p13.2 IL7R interleukin 7 receptor
Mouse 1 459 Il7r interleukin 7 receptor
Rat - - Il7r interleukin 7 receptor
Previous and Unofficial Names
CD127 | interleukin-7 receptor subunit alpha | IL-7 receptor alpha chain
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas

Download all structure-activity data for this target as a CSV file

Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
OSE-127 Hs Antagonist 11.4 pEC50 2
pEC50 11.4 (EC50 4x10-12 M) [2]
Description: In an ELISA binding assay.


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1. Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B et al.. (2006) CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med., 203 (7): 1701-11. [PMID:16818678]

2. Poirier N, Mary C, Vanhove B. (2015) Antibodies directed against CD127. Patent number: WO2015189302. Assignee: Effimune. Priority date: 10/06/2014. Publication date: 17/12/2015.

3. Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R et al.. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med., 203 (7): 1693-700. [PMID:16818676]

4. Shinohara T, Nemoto Y, Kanai T, Kameyama K, Okamoto R, Tsuchiya K, Nakamura T, Totsuka T, Ikuta K, Watanabe M. (2011) Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J. Immunol., 186 (4): 2623-32. [PMID:21217010]

How to cite this page

IL-2 receptor family: Interleukin-7 receptor subunit α. Last modified on 19/07/2017. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,