Interleukin-4 receptor subunit α | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-4 receptor subunit α

Target id: 1697

Nomenclature: Interleukin-4 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Interleukin-4 receptor subunit α has curated data in GtoImmuPdb

Quaternary Structure: Complexes
Interleukin-4 receptor type I
Interleukin-4 receptor type II
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 800 16p12.1-p11.2 IL4R interleukin 4 receptor
Mouse 1 785 7 68.94 cM Il4ra interleukin 4 receptor, alpha
Rat 1 776 1q36 Il4r interleukin 4 receptor
Previous and Unofficial Names
CD124 | IL-4 receptor alpha chain | interleukin 4 receptor, alpha
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas

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Antibody Sp. Action Affinity Units Reference
dupilumab Hs Binding 11.1 pIC50 2
pIC50 11.1 (IC50 8.8x10-12 M) [2]
Description: Value derived from an ELISA-based solution competition assay.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Human immunodeficiency virus type 1, susceptibility to
Synonyms: Human immunodeficiency virus infectious disease [Disease Ontology: DOID:526]
Disease Ontology: DOID:526
OMIM: 609423
Orphanet: ORPHA319269
References:  3
Disease:  IgE responsiveness, atopic; IGER
OMIM: 147050


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1. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. (1997) The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor. N. Engl. J. Med., 337 (24): 1720-5. [PMID:9392697]

2. Martin JH, Huang TT, Fairhurst JL, Papadopoulos NJ. (2009) Cytokine specific immunoglobulin for use in diagnosis, prevention and treatment ,of cell proliferative, inflammatory, allergic, respiratory, autoimmune and arthritic disorders. Patent number: US7608693. Assignee: Regeneron Pharmaceuticals, Inc.. Priority date: 02/10/2006. Publication date: 27/10/2009.

3. Soriano A, Lozano F, Oliva H, García F, Nomdedéu M, De Lazzari E, Rodríguez C, Barrasa A, Lorenzo JI, Del Romero J et al.. (2005) Polymorphisms in the interleukin-4 receptor alpha chain gene influence susceptibility to HIV-1 infection and its progression to AIDS. Immunogenetics, 57 (9): 644-54. [PMID:16189667]

How to cite this page

IL-2 receptor family: Interleukin-4 receptor subunit α. Last modified on 11/04/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,