Interleukin-2 receptor subunit α | IL-2 receptor family | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Interleukin-2 receptor subunit α

Target id: 1695

Nomenclature: Interleukin-2 receptor subunit α

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Interleukin-2 receptor subunit α has curated data in GtoImmuPdb

Quaternary Structure: Complexes
Interleukin-2 receptor
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 272 10p15.1 IL2RA interleukin 2 receptor subunit alpha
Mouse 1 268 Il2ra interleukin 2 receptor, alpha chain
Rat 1 267 Il2ra interleukin 2 receptor subunit alpha
Previous and Unofficial Names
CD25 | TAC antigen | IL2RAC | IL-2R alpha chain | Ly-43 | interleukin 2 receptor
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Antibodies
Key to terms and symbols Click column headers to sort
Antibody Sp. Action Affinity Units Reference
daclizumab Hs Binding >8.0 pKd 1
pKd >8.0 (Kd <1x10-8 M) [1]
basiliximab Hs Binding - -

References

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1. Queen CL, Schneider WP, Selick HE. (1997) Genetic engineering; complementarity zones. Patent number: US5693761. Assignee: Protein Design Labs, Inc.. Priority date: 28/12/1988. Publication date: 02/12/1997.

2. Socié G, Vigouroux S, Yakoub-Agha I, Bay JO, Fürst S, Bilger K, Suarez F, Michallet M, Bron D, Gard P et al.. (2017) A phase 3 randomized trial comparing inolimomab vs usual care in steroid-resistant acute GVHD. Blood, 129 (5): 643-649. [PMID:27899357]

How to cite this page

IL-2 receptor family: Interleukin-2 receptor subunit α. Last modified on 27/10/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1695.