INPP5D | Inositol polyphosphate phosphatases | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 1455

Nomenclature: INPP5D

Abbreviated Name: SHIP1

Family: Inositol polyphosphate phosphatases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     INPP5D has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1189 2q37.1 INPP5D inositol polyphosphate-5-phosphatase D
Mouse - 1191 1 C5 Inpp5d inositol polyphosphate-5-phosphatase D
Rat - 1191 9q35 Inpp5d inositol polyphosphate-5-phosphatase D
Gene and Protein Information Comments
Alternative transcripts and protein isoforms for the human and mouse genes have been identified. We provide details and links for the longest transcripts and isoforms. Further information is available from the Entrez gene links below.
Previous and Unofficial Names
Inositol polyphosphate-5-phosphatase 145 kDa | inositol polyphosphate-5-phosphatase D | phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 | SH2 domain-containing inositol 5'-phosphatase 1 | Src homology 2 domain-containing inositol-5-phosphatase | inositol polyphosphate-5-phosphatase, 145kDa
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
Description Reaction Reference
Hydrolysis of the 5' phosphate of phosphatidylinositol (PtdIns) trisphosphate to PtdIns 3,4 biphosphate 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O <=>> 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
rosiptor Hs Activation - - 5
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
3 alpha-aminocholestane Hs Inhibition - - 1
Physiological Consequences of Altering Gene Expression
SHIP-deficient mice accept allogeneic bone marrow transplants without significant graft-vs-host disease. They produce elevated levels of myeloid suppressor cells which impairs priming of allogeneic T cells, hence the improved tolerance seen in transplant experiments.
Species:  Mouse
References:  2,4
General Comments
Expression of this protein is restricted to hematopoietic cells. It functions as a negative regulator of myeloid cell proliferation and survival. The phosphatase activity of SHIP1 negatively regulates phosphoinositide 3-kinase (PI3K) signalling pathways.


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1. Brooks R, Fuhler GM, Iyer S, Smith MJ, Park MY, Paraiso KH, Engelman RW, Kerr WG. (2010) SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. J. Immunol., 184 (7): 3582-9. [PMID:20200281]

2. Ghansah T, Paraiso KH, Highfill S, Desponts C, May S, McIntosh JK, Wang JW, Ninos J, Brayer J, Cheng F et al.. (2004) Expansion of myeloid suppressor cells in SHIP-deficient mice represses allogeneic T cell responses. J. Immunol., 173 (12): 7324-30. [PMID:15585856]

3. Nickel JC, Egerdie B, Davis E, Evans R, Mackenzie L, Shrewsbury SB. (2016) A Phase II Study of the Efficacy and Safety of the Novel Oral SHIP1 Activator AQX-1125 in Subjects with Moderate to Severe Interstitial Cystitis/Bladder Pain Syndrome. J. Urol., 196 (3): 747-54. [PMID:26968644]

4. Paraiso KH, Ghansah T, Costello A, Engelman RW, Kerr WG. (2007) Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host disease. J. Immunol., 178 (5): 2893-900. [PMID:17312133]

5. Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Wu J, Ogden N, MacRury T et al.. (2013) Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br. J. Pharmacol., 168 (6): 1506-18. [PMID:23121445]

How to cite this page

Inositol polyphosphate phosphatases: INPP5D. Last modified on 12/05/2017. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,