Haem oxygenase 1 | Haem oxygenase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Haem oxygenase 1

Target id: 1441

Nomenclature: Haem oxygenase 1

Abbreviated Name: HO1

Family: Haem oxygenase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Haem oxygenase 1 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 288 22q12.3 HMOX1 heme oxygenase 1
Mouse - - Hmox1 heme oxygenase 1
Rat - - Hmox1 heme oxygenase 1
Previous and Unofficial Names
hsp32 | heme oxygenase 1 | Heox | HEOXG | Hmox | HO-1 | heme oxygenase (decycling) 1
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.14.18
Description Reaction Reference
Protoheme + 3 [reduced NADPH-hemoprotein reductase] + 3 O(2) <=> biliverdin + Fe(2+) + CO + 3 [oxidized NADPH-hemoprotein reductase] + 3 H(2)O

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 1 [PMID: 16821802] Hs Inhibition 5.8 pKi 4
pKi 5.8 (Ki 1.5x10-6 M) [4]
Description: Enzyme isolated from human spleen.
compound 1 [PMID: 16821802] Rn Inhibition 6.1 pIC50 4
pIC50 6.1 (IC50 8x10-7 M) [4]
Description: Enzyme isolated from rat spleen.
View species-specific inhibitor tables

References

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1. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW et al.. (2003) Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J. Immunol., 171 (3): 1572-80. [PMID:12874251]

2. Araujo JA, Zhang M, Yin F. (2012) Heme oxygenase-1, oxidation, inflammation, and atherosclerosis. Front Pharmacol, 3: 119. [PMID:22833723]

3. Romanoski CE, Che N, Yin F, Mai N, Pouldar D, Civelek M, Pan C, Lee S, Vakili L, Yang WP et al.. (2011) Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circ. Res., 109 (5): e27-41. [PMID:21737788]

4. Vlahakis JZ, Kinobe RT, Bowers RJ, Brien JF, Nakatsu K, Szarek WA. (2006) Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors. J. Med. Chem., 49 (14): 4437-41. [PMID:16821802]

Contributors

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How to cite this page

Andreas Papapetropoulos, Csaba Szabo, Timothy R. Billiar, Giuseppe Cirino, David Fulton, Roberto Motterlini.
Haem oxygenase: Haem oxygenase 1. Last modified on 10/07/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1441.