sPLA<sub>2</sub>-1B | Phospholipase A<sub>2</sub> | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 1416

Nomenclature: sPLA2-1B

Family: Phospholipase A2

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     sPLA2-1B has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PLA2G1B phospholipase A2 group IB
Mouse - - Pla2g1b phospholipase A2, group IB, pancreas
Rat - - Pla2g1b phospholipase A2 group IB
Previous and Unofficial Names
GIB | pancreatic PLA2 | PLA2 | PLA2A | PPLA2 | group IB phospholipase A2 | phospholipase A2 group IB pancreas | sPLA2IB | phospholipase A2, group IB (pancreas) | phospholipase A2, group IB, pancreas
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 28xvii [PMID: 8809154] Hs Inhibition 8.9 pIC50 1
pIC50 8.9 (IC50 1.3x10-9 M) [1]
Description: Measured using a chromogenic assay.
compound 12e [PMID: 18605714] Hs Inhibition 7.1 pIC50 3
pIC50 7.1 (IC50 8.4x10-8 M) [3]


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1. Hagishita S, Yamada M, Shirahase K, Okada T, Murakami Y, Ito Y, Matsuura T, Wada M, Kato T, Ueno M et al.. (1996) Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives. J. Med. Chem., 39 (19): 3636-58. [PMID:8809154]

2. Lee HY, Kim MK, Park KS, Shin EH, Bae YS. (2005) Group IB secretory phospholipase A2 stimulates leukotriene B4 production by a unique mechanism in human neutrophils. Biochem. Biophys. Res. Commun., 334 (2): 500-8. [PMID:16005851]

3. Oslund RC, Cermak N, Gelb MH. (2008) Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J. Med. Chem., 51 (15): 4708-14. [PMID:18605714]

How to cite this page

Phospholipase A2: sPLA2-1B. Last modified on 16/02/2017. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1416.