PLCγ1 | Phosphoinositide-specific phospholipase C | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Target id: 1407

Nomenclature: PLCγ1

Family: Phosphoinositide-specific phospholipase C

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     PLCγ1 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1291 20q12 PLCG1 phospholipase C gamma 1
Mouse - - Plcg1 phospholipase C, gamma 1
Rat - - Plcg1 phospholipase C, gamma 1
Previous and Unofficial Names
PLC1 | PLC148 | PLCgamma1 | phosphoinositide phospholipase C-gamma-1 | phospholipase C, gamma 1 | PPLCA | Cded | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | NCKAP3 | phospholipase C
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactor Species Comments Reference
Ca2+ Human
Endogenous activators (Human)
PIP3  [1]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5 [PMID: 10869194] Bt Inhibition 5.0 pIC50 3
pIC50 5.0 (IC50 9.5x10-6 M) [3]


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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 273 (8): 4465-9. [PMID:9468499]

2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol., 6 (3): 218-30. [PMID:16470226]

3. Lee JS, Kim J, Kim BY, Lee HS, Ahn JS, Chang YS. (2000) Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla. J. Nat. Prod., 63 (6): 753-6. [PMID:10869194]

4. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]

5. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J. Biol. Chem., 278 (48): 48474-84. [PMID:13129935]

How to cite this page

Phosphoinositide-specific phospholipase C: PLCγ1. Last modified on 10/07/2018. Accessed on 16/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,