Inducible NOS | Nitric oxide synthases | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Inducible NOS

Target id: 1250

Nomenclature: Inducible NOS

Abbreviated Name: iNOS

Family: Nitric oxide synthases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Inducible NOS has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - NOS2 nitric oxide synthase 2
Mouse - - Nos2 nitric oxide synthase 2, inducible
Rat - - Nos2 nitric oxide synthase 2
Previous and Unofficial Names
NOS2A | HEP-NOS | nitric oxide synthase 2A (inducible, hepatocytes) | Nitric oxide synthase 2 inducible | Nitric oxide synthase 2 inducible macrophage | inducible NO synthase | Nitric oxide synthase 2 / NOSII | inducible macrophage NOS | nitric oxide synthase 2
Database Links
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Enzyme Reaction
EC Number:
Product Species Reference
NO Human
L-citrulline Human
Cofactor Species Comments Reference
Zn2+ Human
heme Human
flavin adenine dinucleotide Human
flavin mononucleotide Human
BH4 Human
oxygen Human
Endogenous Substrate (Human)

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
L-NNA Hs Inhibition 6.2 pKi 2
pKi 6.2 (Ki 6.7x10-7 M) [2]
GW274150 Hs Inhibition 7.2 pIC50 3
pIC50 7.2 (IC50 7x10-8 M) [3]


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1. Adams JL, Smothers J, Srinivasan R, Hoos A. (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov, 14 (9): 603-22. [PMID:26228631]

2. Collins JL, Shearer BG, Oplinger JA, Lee S, Garvey EP, Salter M, Duffy C, Burnette TC, Furfine ES. (1998) N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J. Med. Chem., 41 (15): 2858-71. [PMID:9667974]

3. Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P et al.. (2004) 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J. Med. Chem., 47 (12): 3320-3. [PMID:15163211]


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How to cite this page

Andreas Papapetropoulos, Csaba Szabo, Timothy R. Billiar, Giuseppe Cirino, David Fulton, Roberto Motterlini.
Nitric oxide synthases: Inducible NOS. Last modified on 26/06/2018. Accessed on 19/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,