Arginase II | Arginase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Arginase II

Target id: 1245

Nomenclature: Arginase II

Abbreviated Name: ARG2

Family: Arginase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Arginase II has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ARG2 arginase 2
Mouse - - Arg2 arginase type II
Rat - - Arg2 arginase 2
Previous and Unofficial Names
AII type II arginase | arginase 2 | kidney-type arginase | non-hepatic arginase | Mitochondrial arginase
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human Arginase-2 complexed with inhibitor 9.
Ligand:  compound 9 [PMID: 23472952]
Resolution:  1.6Å
Species:  Human
References:  3
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
2(S)-amino-6-boronohexanoic acid Hs Inhibition 8.1 pKi 2
pKi 8.1 (Ki 8.5x10-9 M) [2]
compound 9 [PMID: 23472952] Hs Inhibition 6.3 pIC50 3
pIC50 6.3 (IC50 5.09x10-7 M) [3]


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1. Adams JL, Smothers J, Srinivasan R, Hoos A. (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov, 14 (9): 603-22. [PMID:26228631]

2. Colleluori DM, Ash DE. (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry, 40 (31): 9356-62. [PMID:11478904]

3. Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M et al.. (2013) Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J. Med. Chem., 56 (6): 2568-80. [PMID:23472952]

How to cite this page

Arginase: Arginase II. Last modified on 16/03/2017. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,