Arginase II | Arginase | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Arginase II

Target id: 1245

Nomenclature: Arginase II

Abbreviated Name: ARG2

Family: Arginase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Arginase II has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ARG2 arginase 2
Mouse - - Arg2 arginase type II
Rat - - Arg2 arginase 2
Previous and Unofficial Names
AII type II arginase | arginase 2 | kidney-type arginase | non-hepatic arginase | Mitochondrial arginase
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human Arginase-2 complexed with inhibitor 9.
PDB Id:  4HZE
Ligand:  compound 9 [PMID: 23472952]
Resolution:  1.6Å
Species:  Human
References:  3
Enzyme Reaction
EC Number: 3.5.3.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
2(S)-amino-6-boronohexanoic acid Hs Inhibition 8.1 pKi 2
pKi 8.1 (Ki 8.5x10-9 M) [2]
compound 9 [PMID: 23472952] Hs Inhibition 6.3 pIC50 3
pIC50 6.3 (IC50 5.09x10-7 M) [3]

References

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1. Adams JL, Smothers J, Srinivasan R, Hoos A. (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov, 14 (9): 603-22. [PMID:26228631]

2. Colleluori DM, Ash DE. (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry, 40 (31): 9356-62. [PMID:11478904]

3. Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M et al.. (2013) Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J. Med. Chem., 56 (6): 2568-80. [PMID:23472952]

How to cite this page

Arginase: Arginase II. Last modified on 16/03/2017. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1245.