Adenosine deaminase | Adenosine turnover | IUPHAR Guide to IMMUNOPHARMACOLOGY

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Adenosine deaminase

Target id: 1230

Nomenclature: Adenosine deaminase

Abbreviated Name: ADA

Family: Adenosine turnover

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: ON :     Adenosine deaminase has curated data in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 363 20q13.12 ADA adenosine deaminase
Mouse - 352 2 84.44 cM Ada adenosine deaminase
Rat - 352 3q42 Ada adenosine deaminase
Previous and Unofficial Names
ADA1 | Adenosine aminohydrolase
Database Links
BRENDA
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.5.4.4 Adenosine + H2O = inosine + NH3
Rank order of affinity (Human)
2'-deoxyadenosine > adenosine

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
EHNA Hs Inhibition 8.8 pKi 1
pKi 8.8 [1]
pentostatin Hs Inhibition 10.8 pIC50 1
pIC50 10.8 [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Omenn syndrome
Disease Ontology: DOID:0060010
Orphanet: ORPHA39041
References:  2-3
Disease:  Severe combined immunodeficiency due to adenosine deaminase deficiency
Synonyms: Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase [OMIM: 102700]
Disease Ontology: DOID:5810
OMIM: 102700
Orphanet: ORPHA277

References

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1. Agarwal RP, Spector T, Parks Jr RE. (1977) Tight-binding inhibitors--IV. Inhibition of adenosine deaminases by various inhibitors. Biochem. Pharmacol., 26 (5): 359-67. [PMID:849330]

2. Roifman CM, Zhang J, Atkinson A, Grunebaum E, Mandel K. (2008) Adenosine deaminase deficiency can present with features of Omenn syndrome. J. Allergy Clin. Immunol., 121 (4): 1056-8. [PMID:18243287]

3. Villa A, Notarangelo LD, Roifman CM. (2008) Omenn syndrome: inflammation in leaky severe combined immunodeficiency. J. Allergy Clin. Immunol., 122 (6): 1082-6. [PMID:18992930]

Contributors

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How to cite this page

Detlev Boison.
Adenosine turnover: Adenosine deaminase. Last modified on 27/01/2017. Accessed on 18/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1230.