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Targets Associated to Immuno Cell Types - Stromal cells

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The Stromal cells category includes the following Cell Ontology parent terms:

stromal cell (CL:0000499) - A connective tissue cell of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.

GPCRs
GtoPdb receptor name (family) Cell Type Association Comments Cell Ontology Associations Immunopharmacology Comments
S1P1 receptor
(Lysophospholipid (S1P) receptors)
Pharmacological targeting of the S1P/S1PR1 signalling pathway (and its regulation of MMP-2-mediated extracellular matrix remodelling) in bone marrow-derived mesenchymal stromal cells (BM-MSCs) may potentiate the beneficial effects of these cells in tissue repair. Exploiting S1P/S1PR1 signalling is suggested as a novel option for BM-MSC-based therapy for potential in the regenerative medicine field.
    S1P1R activation by agonists downregulates allergic inflammation (i.e. it has an inhibitory effect) [1-2,7] ...