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The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list

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Ligand name ID Synonyms
A Back to top
852A 9025
A286982 6592 A 286982, A-286982
A438079 4118 A 438079, A-438079
abatacept 6891 BMS-188667, CTLA4-IgG4m, Orencia®, RG-1046, RG-2077
abediterol 9326 LAS-100977
AbGn-168H 10013 AbGn-168, neihulizumab
ABT-737 8320 ABT 737, ABT737, compound 2 [PMID 17256834]
AC430 9177 AC-430
acalabrutinib 8912 ACP-196, Calquence®, Example 6 [US20140155385 A1]
Ac-SDKP 10060 goralatide, seraspenide
ACT-389949 9511
ACTH  {Sp: Human} 3633 Acthar®, adrenocorticotropic hormone (1-39), corticotropin
acumapimod 9203 BCT 197, BCT-197, BCT197, compound A [WO2013139809]
adalimumab 4860 D2E7, FKB327, Humira®
adavivint 9620 SM0-4690, SM04690
(-)-adrenaline 479 adrenalin, Auvi-Q®, Epipen®, l-adrenaline, L-epinephrine, levoepinephrine
adrenomedullin  {Sp: Human} 683 AM
AF12198 4861 AF 12198, AF-12198
AFM13 10067 AFM 13, AFM-13
agatolimod 9843 CpG 7909, CpG7909, PF 3512676, PF-3512676, ProMune, VaxImmune
AH10-7 9899
AH6809 1896 AH 6809, AH-6809
ajulemic acid 9772 CPL-7075, CPL7075, CT-3, IP-751, IP751, lenabasum (proposed INN)
AL-78898A 9219 4(1MeW), POT-4
alcaftadine 7587 Lastacaft®, R-89674
alefacept 6787 Amevive®, BG 9273, BG 9712, BG-9273, BG-9712, Lfa3Tip
alemtuzumab 6770 campath 1H, Campath®, campath-1H, Lemtrada®
alimemazine 7237 Nedeltran®, trimeprazine
alpelisib 7955 BYL 719, BYL-719, NVP-BYL719
3 alpha-aminocholestane 9564 3AC, 3 α-aminocholestane
ALT-803 9615
alvelestat 6476 AZD 9668, AZD-9668, AZD9668, KB-105160
amcinonide 7060 CL-34699, Cyclocort®
amelubant 8463 BIIL 284, BIIL-284
AMG319 8917 AMG 319, AMG-319
AMG820 9106
aminopyridine 2 10051
amiselimod 9319 Example 1 [US20090137530], MT-1303, MT1303
amiselimod phosphate 9491 amiselimod-P
amlexanox 7113 AA-673, Amlexanox®, Aphthasol®, CHX-3673
anakinra 6972 antril, Kineret®
anatumomab mafenatox 9947 5T4FabV13SEAD227A, ABR 214936, ABR-214936, ABR214936, pMB125, PNU 214936, PNU-214936, PNU214936, TTS-CD2
ancriviroc 804 SCH 351125, SCH-351125, SCH-C
andecaliximab 9510 GS-5745, GS5745
andrographolide 9675
anifrolumab 8258 MDX-1333, MEDI-546
apafant 1860 WEB 2086 BS, WEB-2086
apilimod 9859 STA 5326, STA-5326, STA5326
apratastat 6482 compound 5h [PMID: 16426848], TMI-05, TMI005
apremilast 7372 CC-10004, Otezla®
APRIL  {Sp: Human} 5068 A proliferation-inducing ligand, TALL2, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TRDL-1, ZTNF2
arformoterol 7479 Brovana®, YM-08316
ARGX-110 9778 ARGX110, clone 41D12, cusatuzumab (proposed INN)
(R)-ARN2508 9000 compound (-)-10r [PMID: 26774927], example 19 [WO2014023643]
(S)-ARN2508 8999 compound (+)-10r [PMID: 26774927], example 20 [WO2014023643]
ARRY-382 9108 ARRY 382, ARRY382
AS101 437 ammonium tri-chloro(dioxoethylene-O,O'-)tellurate, AS 101, AS-101
asimadoline 9279 EMD 61 753, EMD 61753, EMD-61753
asivatrep 9621 Example 230 [US7858621], PAC-14028
ASN002 10000
ASP4058 9569 ASP-4058
aspirin 4139 Acetophen®, acetylsalicylic acid, Aspirin®
aspirin-triggered resolvin D1 6239 AT-Resolvin D1, AT-RvD1
AT38 9020 [3-(aminocarbonyl)furoxan-4-yl]methyl salicylate
atacicept 9517 TACI-Fc, TACI-Ig
ATB-346 9534 ATB 346
atezolizumab 7990 MPDL3280A, Tecentriq®
atracurium 9537 atracurium besilate, atracurium dibesylate, BW 33A, Tracrium®
auranofin 6306 Ridaura®, SK&F-39162, SK-39162
avacopan 9450 CCX-168, CCX168
AVE 0991 5579 AVE-0991, AVE0991
avelumab 8735 Bavencio®, MSB-0010718C, MSB0010718C
AZ13102909 9577 AZ909
AZ3451 9560
AZ7188 9586
AZ8838 9585
azacitidine 6796 5-AZAC, 5-azacytidine, ladakamycin, U-18496, Vidaza®
azapro-3 9221
azatadine 7119 Optimine®, SCH-10649
azathioprine 7120 Azasan®, BW-57-322, Imuran®
AZD1236 7844 AZD 1236, AZD-1236
AZD1678 9679 AZD-1678, compound 49 [PMID: 28947948]
AZD1981 7680 AZD 1981, AZD-1981
AZD2098 9678 AZD-2098, compound 47 [PMID: 28947948]
AZD2423 7825 AZD 2423, AZD-2423
AZD5069 8948
AZD5672 7686 AZD 5672, AZD-5672
AZD6605 7823 AZ 11920155, AZ-11920155, AZ11920155, AZD 6605, AZD-6605
AZD6703 7687 AZ 12012199, AZ-12012199, AZ12012199, AZD 6703, AZD-6703
AZD7594 9325 AZ13189620, compound 15m [PMID: 28937774]
AZD7986 9412 compound 30
AZD8848 9256 DSP-3025
AZD9056 7826 AZD 9056, AZD-9056
AZD9567 9812 AZD 9567, AZD-9567, compound 15 [PMID: 29424542], example 1 [WO2016046260A1]
azelaic acid 7484 Azelex®, Finacea®, ZK-62498
AZ11657312 (salt free) 7722
 
B Back to top
bafetinib 7906 INNO-406, Lyn-IN-1, NS-187
BAFF  {Sp: Human} 5069 B cell-activating factor, CD257 antigen, dendritic cell-derived TNF-like molecule
balamapimod 9925 MKI-833, MKI833
bardoxolone 2717 CDDO, RTA-401
baricitinib 7792 INCB-028050, INCB028050, LY-3009104, LY3009104, Olumiant®
basiliximab 6879 CHI-621, L04AC02, SDZ-CHI-621, Simulect®
BAYu9773 3381 BAY u9773, BAY-u 9773
beclometasone 7059 beclomethasone, SCH-18020W
beclometasone dipropionate 5894 beclomethasone dipropionate, Beconase®, Qnasl®, Vancenase®
begelomab 8691 Begendina&rg; (proprietary name), BT 5/9, SAND 26
belatacept 6892 BMS-224818, LEA29Y, Nulojix®
belimumab 6887 Benlysta®, hBlySmAb-1.1, LimphoStat-B, lymphostat-B
belnacasan 9035 VX-765
benralizumab 7674 BIW-8405, Fasenra®, KHK4563, MEDI-563
bentamapimod 9926 AS-602801, AS602801, PGL-5001, PGL5001
benzodrocortisone 9731 compound 1 [WO2013071010], hydrocortisone 17-benzoate
3beta-Hydroxy-20(29)-lupene 9028 Fagarasterol, Lupeol
betamethasone 7061 SCH-4831
BGB-3111 9591
BGB-A317 9592 hu317-1/IgG4mt2, tislelizumab (proposed INN)
BI-1935 9717 BI 1935, example 3 [WO2007067836]
BI-1950 9719
BI-2545 9791 BI2545, compound 19 [PMID: 29259743]
BI605906 9357 3-Amino-4-(1,1-difluoro- propyl)-6-(4-methanesulfonyl- piperidin-1-yl)-thieno[2,3- b]pyridine-2-carboxylic acid amide, compound 115 [US20070293533]
BI 653048 9715 (R)-39, BI 653048 BS H3PO4, BI-653048, BI653048
BI 665915 9716 BI-665915, compound 69 [PMID: 25671290]
BI-6901 9714 BI 6901, BI 6901, BI6901, eut-22
bihelical apoA-I mimetic peptide 5A 9183 5A peptide
bimekizumab 9411 CA028_0496, CDP4940, gL7gH9, UCB-4940, UCB4940, Zu-G1
bimosiamose 9049 compound 15e [PMID: 9544210], TBC 1269, TBC-1269, TBC1269
BIRT 377 9720 BIRT-377
blinatumomab 7384 Blincyto®, bscCD19xCD3, MEDI-538, MT-103, MT103
blisibimod 9518 A-623, AGP3 peptibody, AMG 623, Fc-Agp-3
BLZ945 8250 BLZ 945, BLZ-945
BML-281 9664 compound 3 [PMID: 18642892]
BMS-1166 9608 compound 2c [PMID: 28613862]
BMS-202 9607 compound 1c [PMID: 28613862], PD1-PDL1 inhibitor 2
BMS-345541 5669 BMS 345541, BMS345541
BMS-509744 9994 BMS 509744, BMS509744, compound 3 [PMID:16682193]
BMS-561392 6509 BMS 561392, BMS561392, DPC-333
BMS-582949 7838 BMS 582949, BMS582949, PS 540446, PS-540446, PS540446
BMS-681 9430 compound 13d [PMID: 25893046]
BMS-817399 9497 compound 29 [PMID: 25101488]
BMS-986142 9857 BMS986142, compound 14f [PMID: 27583770]
BMS-986195 9869 BMS986195, Example 223 [US20160115126A1]
BMS-986205 9707 BMS986205
bosutinib 5710 Bosulif®, SK 606, SK-606, SKI 606
brazikumab 9293 AMG 139, AMG-139, MEDI2070
brentuximab vedotin 6772 Adcetris®, anti-CD30 ADC SGN-35, SGN 35
briakinumab 9213 ABT-874, J-695, J695, Ozespa
brimapitide 9101 AM-111, D-JNKI-1, XG-102
brimonidine 520 Alphagan®, Lumify®, Mirvaso®, UK14,304, UK14304
BRL-15572 10 BRL 15572, BRL-15,572, BRL15572
brodalumab 7540 AMG-827, AMG827, Kyntheum®, Lumicef®, Siliq®
bromfenac 7131 AHR-10282B, Bromday®, Prolensa®, Xibrom®
BsAb (CD89-CD20) 9833
BTP2 2438 YM-58483
budesonide 7434 Entocort®, Pulmicort®, S-1320, Uceris®
butyric acid 1059 butanoic acid, butyrate, C4
BX 471 767 BX-471, BX-741
BX-795 8006 BX 795, BX795
 
C Back to top
C108297 9180 Compound 52 [PMID:18226897]
C391 9570 compound 5 [PMID: 27994760]
C646 7004
C5a  {Sp: Human} 573 C5a anaphylatoxin, complement component C5a, human complement protein
cabiralizumab 9107 BMS-986227, FPA-008, FPA008
camrelizumab 9758 INCSHR1210, SHR-1210
canakinumab 6773 ACZ 885, ACZ885, Ilaris®
carprofen 7141 Ro-205720000
CBS-3595 9610
CC-885 9224
CCL1  {Sp: Human} 812 I309, TCA-3
CCL11  {Sp: Human} 769 eotaxin
CCL13  {Sp: Human} 770 monocyte chemotactic protein-4
CCL14  {Sp: Human} 753 CCL14a, CKβ1, haemofiltrate CC chemokine 1 (HCC-1), HCC-1(1-74)
CCL15  {Sp: Human} 754 Lkn-1 [Leukotactin-1], macrophage inflammatory protein-1δ, MIP-1δ
CCL16  {Sp: Human} 1272
CCL17  {Sp: Human} 797 TARC, thymus- and activation-regulated chemokine
CCL18  {Sp: Human} 4382 macrophage inflammatory protein 4, small-inducible cytokine A18
CCL19  {Sp: Human} 810 β-chemokine exodus-3, ck β-11, ckβ11, MIP-3β
CCL2  {Sp: Human} 771
CCL20  {Sp: Human} 808 LARC, liver and activation-regulated chemokine, macrophage inflammatory protein-3α, MIP-3α
CCL21  {Sp: Human} 811 ckβ9, TCA-4
CCL22  {Sp: Human} 798 dc/β-ck, macrophage-derived chemokine, STCP1
CCL23  {Sp: Human} 755 ckβ8-1, myeloid progenitor inhibitor factor-1
CCL24  {Sp: Human} 775 eotaxin-2
CCL25  {Sp: Human} 817
CCL26  {Sp: Human} 776 MIP-4α, PTEC
CCL27  {Sp: Human} 3646
CCL28  {Sp: Human} 3649
CCL3  {Sp: Human} 756 macrophage inflammatory protein-1α, MIP-1α
CCL4  {Sp: Human} 757 HC21, macrophage inflammatory protein-1β, MIP-1β
CCL5  {Sp: Human} 758 eosinophil chemotactic cytokine [EoCP], regulated upon activation normal T cell expressed and secreted (RANTES)
CCL7  {Sp: Human} 759
CCL8  {Sp: Human} 772 monocyte chemotactic protein-2
CCL1  {Sp: Mouse} 4404
CCL11  {Sp: Mouse} 787 murine eotaxin
CCL12  {Sp: Mouse} 4435
CCL19  {Sp: Mouse} 4417
CCL2  {Sp: Mouse} 4406
CCL20  {Sp: Mouse} 4418
CCL22  {Sp: Mouse} 4420
CCL24  {Sp: Mouse} 4421
CCL25  {Sp: Mouse} 4422
CCL27  {Sp: Mouse} 4462
CCL28  {Sp: Mouse} 4463
CCL3  {Sp: Mouse} 4408
CCL4  {Sp: Mouse} 4410
CCL7  {Sp: Mouse} 4413
CCL8  {Sp: Mouse} 4415
CCL9  {Sp: Mouse} 4434
CCL5  {Sp: Mouse, Rat} 4412
CCL11  {Sp: Rat} 4416
CCL2  {Sp: Rat} 4407
CCL20  {Sp: Rat} 4419
CCL3  {Sp: Rat} 4409
CCL4  {Sp: Rat} 4411
CCL7  {Sp: Rat} 4414
Ccl21a  {Sp: Mouse} 8651 6Ckine-Ser, Exodus-2
Ccl21b  {Sp: Mouse} 8652 6Ckine-Leu, Exodus-2
CCR2-RA-[R] 9431 analog 49 (Dasse et al., 2007)
CDP840 9330 CDP 840, CDP-840
celecoxib 2892 Celecox®, Onsenal®
cenerimod 9824 ACT-334441
cenicriviroc 801 TAK 652, TAK-652, TAK652, TBR-652
cerdulatinib 8957 PRT 062070, PRT-062070, PRT-2070, PRT062070
certolizumab pegol 6774 CDP870, Cimzia®, PHA 738144
cetirizine 1222 Reactine®, Zyrtec®
CFZ533 9802 CFZ-533, iscalimab (proposed INN), NVP-CFZ533, OM11-62MF
CG200745 10055 CG-2, CG-200745, HDCG-0745
CGI1746 8066 CGI 1746, CGI-1746
CGI560 9264 CGI-560
CH-4051 9844 Formula (10) [WO2012078708A1]
CHMFL-BTK-11 9516
cibinetide 9677 ARA 290, ARA-290, PH-BSP, PHBSP
cicaprost 1917 ZK 96480, ZK-96480
ciclesonide 7469 Alvesco®, Omnaris®, RPR-251526
cilomilast 7407 SB-207499
cipemastat 6466 Ro 28-2653
clazakizumab 9195 ALD-518, ALD518, BMS-945429
clemastine 6063 HS-592, meclastin, Tavegil®, Tavist®
clobenpropit 1223 VUF 9153, VUF-9153
clobetasol propionate 7062 CCI-4725, Clobex®, Dermovate®, GR 2/925, Temovate®
clobetasone 9088 Eumovate®
clodronic acid 9605 Bonefos®, Clasteon ®, clodronate, Loron®
clofazimine 9184 Lamprene®
clopidogrel (active metabolite) 1772
CNX-774 9266
complement C3  {Sp: Human} 9414
complement C5  {Sp: Human} 8712
compound 48/80 5531
compound 3a [Pipionne et al, 2018] 9965
compound 12a [PMID: 29031075] 9684
compound 19a [PMID: 26506089] 9842
compound 5b [PMID: 29457898] 9835
compound 18c [PMID: 25901531] 9227
compound 7c [PMID: 22041175] 9931
compound 8c [PMID: 28760529] 9671
Compound 9 [doi:10.26434/chemrxiv.7072592.v1] 10083
compound 17d [PMID: 23099093] 8196
compound 7d [PMID: 29672049] 9937
compound 5e [PMID: 28580438] 9712
compound 20f [PMID: 28520415] 9961
compound 7f [PMID: 29191554] 9794 example 32 [WO2011078413]
compound 7f [PMID: 29283260] 9780
compound 2g [PMID: 27390066] 9682
compound 4g [PMID: 22220592] 9236 Example XCII [US20160175314]
compound 4g [PMID: 2680437] 9198
compound 8ic [PMID: 19081254] 9478 CCR4 Antagonist
compound III [PMID: 24045148] 9709
compound II [PMID: 21329883] 9579
compound 5i [PMID: 24099220] 8223 GNF-PF-3777
compound 17l [PMID: 26288691] 10035
compound 29 [Moslin et al., 2017] 9992
compound 12p [Larson et al., 2017] 9690
compound 11 [PMID: 29442501] 9819
compound 12 [PMID: 27448772] 9453
compound 15 [PMID: 25411721] 9078 example 252 [WO2007110237]
compound 15 [PMID: 29852070] 9997
compound 16 [PMID: 26794040] 9223
compound 17 [PMID: 29741897] 10005
compound 1 [PMID: 24930776] 9092 DB36
compound 1 [PMID: 28611375] 9673
compound 21 [PMID: 22802221] 6918 C21
compound 21 [PMID: 24900635] 8187
compound 24 [PMID: 26987013 ] 9252
compound 25 [PMID: 28038940] 9700
compound 28 [PMID: 28671460] 9670
compound 36 [PMID: 21958547] 9391
compound 37 [PMID: 29193967] 9797
compound 3 [PMID: 28603634] 9628
compound 3 [PMID: 29633584] 9960
compound 41 [PMID: 25000588] 9349
compound 43 [PMID: 26751273] 9492
compound 47 [PMID: 28737909] 9646
compound 52 [PMID: 28541707] 10001
compound 6 [PMID: 25874594] 9178
compound 76 [PMID: 28657314] 9609
compound 9 [PMID: 26006010] 9761
compound 3v [PMID: 27390066] 9683
compound 1 [WO2012007375] 8084
compound 7 [WO2012007375] 8085
compstatin