TL1A   Click here for help

GtoPdb Ligand ID: 5071

Synonyms: Tumor necrosis factor ligand superfamily member 15, membrane form
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: TL1A occurs as both membrane‐bound and soluble forms. It principally functions as a negative modulator of epithelial cell proliferation. Inhibiting the TL1A/death receptor 3 (TNFRSF25) pathway has been proposed as mechanism to treat inflammatory bowel disease [1]. In addition, TL1A has been associated with tumourigenesis and progression of some gastrointestinal malignancies [3,5,7], making it a target of interest for the development of novel anti-cancer drugs.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Tumor necrosis factor superfamily ligands
Synonyms Click here for help
Tumor necrosis factor ligand superfamily member 15, membrane form
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF15 TNF superfamily member 15 Human prepro-tumor necrosis factor ligand superfamily member 15 MGC129934, MGC129935, TL1, TL1A, TNF ligand-related molecule 1, TNF superfamily ligand TL1A, tumor necrosis factor (ligand) superfamily, member 15, tumor necrosis factor superfamily member 15, vascular endothelial cell growth inhibitor, vascular endothelial growth inhibitor-192A, VEGI, VEGI192A
Database Links Click here for help
CATH/Gene3D 2.60.120.40
Ensembl Gene ENSG00000181634 (Hs)
GtoPdb PubChem SID 178101764
Human Protein Atlas ENSG00000181634 (Hs)
UniProtKB O95150 (Hs)
Wikipedia TNFSF15